Cerebrospinal Fluid Cytokine Expression Profile in Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy

Serena Bonin, Nunzia Zanotta, Arianna Sartori, Alessio Bratina, Paolo Manganotti, Paolo Manganotti, Giusto Trevisan, Giusto Trevisan, Manola Comar, Manola Comar

Research output: Contribution to journalArticlepeer-review


© 2017 Taylor & Francis. Background: Cerebrospinal fluid (CSF) analysis in patients with particular neurologic disorders is a powerful tool to evaluate specific central nervous system inflammatory markers for diagnostic needs, because CSF represents the specific immune micro-environment to the central nervous system. Methods: CSF samples from 49 patients with multiple sclerosis (MS), chronic inflammatory demyelinating polyneuropathy (CIDP), and non-inflammatory neurologic disorders (NIND) as controls were submitted to protein expression profiles of 47 inflammatory biomarkers by multiplex Luminex bead assay to investigate possible differences in the inflammatory process for MS and CIDP. Results: Our results showed differences in CSF cytokine levels in MS and CIDP; in particular, IL12 (p40) was significantly highly expressed in MS in comparison with CIDP and NIND, while SDF-1α and SCGF-β were significantly highly expressed in CIDP cohort when compared to MS and NIND. IL-9, IL-13, and IL-17 had higher expression levels in NIND if compared with the other groups. Conclusions: Our study showed that, despite some common pathogenic mechanisms, central and peripheral nervous system demyelinating diseases, such as MS and CIDP, differ in some specific inflammatory soluble proteins in CSF, underlining differences in the immune response involved in those autoimmune diseases.
Original languageEnglish
Pages (from-to)135-145
Number of pages11
JournalImmunological Investigations
Issue number2
Publication statusPublished - Feb 17 2018


  • central and peripheral nervous system
  • cerebrospinal fluid
  • chronic inflammatory demyelinating polyneuropathy
  • inflammatory biomarkers
  • Multiple sclerosis


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