Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging

Maria Marcella Laganà, Anamika Chaudhary, Deepa Balagurunathan, David Utriainen, Paul Kokeny, Wei Feng, Pietro Cecconi, David Hubbard, E. Mark Haacke

Research output: Contribution to journalArticle

Abstract

We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular vein (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck. Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic (ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow duration and its onset from systole. We tested if these variables were statistically different among different MS phenotypes and between ST and NST MS patients. The delay between the beginning of systole and the CSF outflow was higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and CSF flow timing but not CSF flow amplitude.

Original languageEnglish
Pages (from-to)349-358
Number of pages10
JournalCurrent Neurovascular Research
Volume11
Issue number4
Publication statusPublished - Jan 1 2014

Fingerprint

Hydrodynamics
Jugular Veins
Multiple Sclerosis
Cerebrospinal Fluid
Magnetic Resonance Imaging
Systole
Phenotype
Phlebography
Carotid Arteries
Angiography
Neck
Population

Keywords

  • Cerebrospinal fluid
  • Multiple sclerosis
  • Phase contrast mri
  • Venous stenosis

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Laganà, M. M., Chaudhary, A., Balagurunathan, D., Utriainen, D., Kokeny, P., Feng, W., ... Haacke, E. M. (2014). Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging. Current Neurovascular Research, 11(4), 349-358.

Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging. / Laganà, Maria Marcella; Chaudhary, Anamika; Balagurunathan, Deepa; Utriainen, David; Kokeny, Paul; Feng, Wei; Cecconi, Pietro; Hubbard, David; Haacke, E. Mark.

In: Current Neurovascular Research, Vol. 11, No. 4, 01.01.2014, p. 349-358.

Research output: Contribution to journalArticle

Laganà, MM, Chaudhary, A, Balagurunathan, D, Utriainen, D, Kokeny, P, Feng, W, Cecconi, P, Hubbard, D & Haacke, EM 2014, 'Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging', Current Neurovascular Research, vol. 11, no. 4, pp. 349-358.
Laganà, Maria Marcella ; Chaudhary, Anamika ; Balagurunathan, Deepa ; Utriainen, David ; Kokeny, Paul ; Feng, Wei ; Cecconi, Pietro ; Hubbard, David ; Haacke, E. Mark. / Cerebrospinal fluid flow dynamics in multiple sclerosis patients through phase contrast magnetic resonance imaging. In: Current Neurovascular Research. 2014 ; Vol. 11, No. 4. pp. 349-358.
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