Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities: is it time to assess the definitions?

Mattia Trunfio, Carmela Pinnetti, Emanuele Focà, Francesca Bai, Gaetano Maffongelli, Luigi Celani, Paola Cinque, Anna Celotti, Massimo Andreoni, Antonella D'Arminio Monforte, Gabriella D'Ettorre, Andrea Antinori, Andrea Calcagno

Research output: Contribution to journalArticle

Abstract

No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.

Original languageEnglish
JournalAIDS (London, England)
DOIs
Publication statusE-pub ahead of print - Nov 27 2018

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