Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

Andrea Arighi; Andrea Di Cristofori; Chiara Fenoglio; Stefano Borsa; Marianna D'Anca; Giorgio Giulio Fumagalli; Marco Locatelli; Giorgio Carrabba; Anna Margherita Pietroboni; Laura Ghezzi; Tiziana Carandini; Annalisa Colombi; Marta Scarioni; Milena Alessandra De Riz; Maria Serpente; Paolo Maria Rampini; Elio Scarpini; Daniela Galimberti

doi:10.3233/JAD-190119

Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

Andrea Arighi, Andrea Di Cristofori, Chiara Fenoglio, Stefano Borsa, Marianna D'Anca, Giorgio Giulio Fumagalli, Marco Locatelli, Giorgio Carrabba, Anna Margherita Pietroboni, Laura Ghezzi, Tiziana Carandini, Annalisa Colombi, Marta Scarioni, Milena Alessandra De Riz, Maria Serpente, Paolo Maria Rampini, Elio Scarpini, Daniela Galimberti

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.

Original language	English
Pages (from-to)	663-669
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	69
Issue number	3
DOIs	https://doi.org/10.3233/JAD-190119
Publication status	Published - Jan 1 2019

Keywords

Alzheimer's disease
Aquaporin 4
glymphatic system
normal pressure hydrocephalus

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

Access to Document

10.3233/JAD-190119

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Arighi, A., Di Cristofori, A., Fenoglio, C., Borsa, S., D'Anca, M., Fumagalli, G. G., Locatelli, M., Carrabba, G., Pietroboni, A. M., Ghezzi, L., Carandini, T., Colombi, A., Scarioni, M., De Riz, M. A., Serpente, M., Rampini, P. M., Scarpini, E., & Galimberti, D. (2019). Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease? Journal of Alzheimer's Disease, 69(3), 663-669. https://doi.org/10.3233/JAD-190119

Cerebrospinal Fluid Level of Aquaporin4 : A New Window on Glymphatic System Involvement in Neurodegenerative Disease? / Arighi, Andrea; Di Cristofori, Andrea; Fenoglio, Chiara; Borsa, Stefano ; D'Anca, Marianna; Fumagalli, Giorgio Giulio; Locatelli, Marco ; Carrabba, Giorgio ; Pietroboni, Anna Margherita; Ghezzi, Laura; Carandini, Tiziana; Colombi, Annalisa; Scarioni, Marta; De Riz, Milena Alessandra; Serpente, Maria; Rampini, Paolo Maria; Scarpini, Elio ; Galimberti, Daniela.

In: Journal of Alzheimer's Disease, Vol. 69, No. 3, 01.01.2019, p. 663-669.

Research output: Contribution to journal › Article › peer-review

Arighi, A, Di Cristofori, A, Fenoglio, C, Borsa, S , D'Anca, M, Fumagalli, GG, Locatelli, M , Carrabba, G , Pietroboni, AM, Ghezzi, L, Carandini, T, Colombi, A, Scarioni, M, De Riz, MA, Serpente, M, Rampini, PM, Scarpini, E & Galimberti, D 2019, 'Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?', Journal of Alzheimer's Disease, vol. 69, no. 3, pp. 663-669. https://doi.org/10.3233/JAD-190119

Arighi, Andrea ; Di Cristofori, Andrea ; Fenoglio, Chiara ; Borsa, Stefano ; D'Anca, Marianna ; Fumagalli, Giorgio Giulio ; Locatelli, Marco ; Carrabba, Giorgio ; Pietroboni, Anna Margherita ; Ghezzi, Laura ; Carandini, Tiziana ; Colombi, Annalisa ; Scarioni, Marta ; De Riz, Milena Alessandra ; Serpente, Maria ; Rampini, Paolo Maria ; Scarpini, Elio ; Galimberti, Daniela. / Cerebrospinal Fluid Level of Aquaporin4 : A New Window on Glymphatic System Involvement in Neurodegenerative Disease?. In: Journal of Alzheimer's Disease. 2019 ; Vol. 69, No. 3. pp. 663-669.

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abstract = "Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.",

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