Abstract
Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.
| Original language | English |
|---|---|
| Pages (from-to) | 663-669 |
| Number of pages | 7 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 69 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Alzheimer's disease
- Aquaporin 4
- glymphatic system
- normal pressure hydrocephalus
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Cerebrospinal Fluid Level of Aquaporin4 : A New Window on Glymphatic System Involvement in Neurodegenerative Disease? / Arighi, Andrea; Di Cristofori, Andrea; Fenoglio, Chiara; Borsa, Stefano; D'Anca, Marianna; Fumagalli, Giorgio Giulio; Locatelli, Marco; Carrabba, Giorgio; Pietroboni, Anna Margherita; Ghezzi, Laura; Carandini, Tiziana; Colombi, Annalisa; Scarioni, Marta; De Riz, Milena Alessandra; Serpente, Maria; Rampini, Paolo Maria; Scarpini, Elio; Galimberti, Daniela.
In: Journal of Alzheimer's Disease, Vol. 69, No. 3, 01.01.2019, p. 663-669.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrospinal Fluid Level of Aquaporin4
T2 - A New Window on Glymphatic System Involvement in Neurodegenerative Disease?
AU - Arighi, Andrea
AU - Di Cristofori, Andrea
AU - Fenoglio, Chiara
AU - Borsa, Stefano
AU - D'Anca, Marianna
AU - Fumagalli, Giorgio Giulio
AU - Locatelli, Marco
AU - Carrabba, Giorgio
AU - Pietroboni, Anna Margherita
AU - Ghezzi, Laura
AU - Carandini, Tiziana
AU - Colombi, Annalisa
AU - Scarioni, Marta
AU - De Riz, Milena Alessandra
AU - Serpente, Maria
AU - Rampini, Paolo Maria
AU - Scarpini, Elio
AU - Galimberti, Daniela
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.
AB - Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.
KW - Alzheimer's disease
KW - Aquaporin 4
KW - glymphatic system
KW - normal pressure hydrocephalus
UR - http://www.scopus.com/inward/record.url?scp=85067118375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067118375&partnerID=8YFLogxK
U2 - 10.3233/JAD-190119
DO - 10.3233/JAD-190119
M3 - Article
C2 - 31156164
AN - SCOPUS:85067118375
VL - 69
SP - 663
EP - 669
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -