Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

Andrea Arighi, Andrea Di Cristofori, Chiara Fenoglio, Stefano Borsa, Marianna D'Anca, Giorgio Giulio Fumagalli, Marco Locatelli, Giorgio Carrabba, Anna Margherita Pietroboni, Laura Ghezzi, Tiziana Carandini, Annalisa Colombi, Marta Scarioni, Milena Alessandra De Riz, Maria Serpente, Paolo Maria Rampini, Elio Scarpini, Daniela Galimberti

Research output: Contribution to journalArticlepeer-review

Abstract

Aquaporin4 (AQP4) is a water channel protein located at astrocyte foot processes that plays a role in glymphatic system, a highly organized fluid transport pathway which seems to be involved in Alzheimer's disease (AD) and normal pressure hydrocephalus (NPH) pathophysiology. Cerebrospinal fluid (CSF) AQP4 levels were determined in 11 patients with AD, 10 patients with NPH, and 9 controls. We found significantly reduced AQP4 in AD patients, a trend in reduction in NPH patients, and a correlation between AQP4 and amyloid-β CSF levels. This study indicates the potential role of AQP4 and glymphatic system in neurodegenerative diseases pathophysiology.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalJournal of Alzheimer's Disease
Volume69
Issue number3
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Alzheimer's disease
  • Aquaporin 4
  • glymphatic system
  • normal pressure hydrocephalus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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