Abstract
Cerebrospinal fluid lymphocytes from six human immunodeficiency virus (HIV)-infected and three seronegative patients were studied for in vitro synthesis of HIV-specific antibody by means of Western blot analysis of lymphocyte culture supernatants. All the HIV-positive subjects showed in vitro production of HIV-specific IgG, regardless of neurological involvement, while no specific antibody synthesis was detected in seronegative individuals. These data provide the first direct evidence that HIV-specific antibody in cerebrospinal fluid is due to intrathecal synthesis.
Original language | English |
---|---|
Pages (from-to) | 181-186 |
Number of pages | 6 |
Journal | Journal of Neuroimmunology |
Volume | 18 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1988 |
Keywords
- Acquired immunodeficiency syndrome
- Antibody synthesis, in vitro
- Cerebrospinal fluid
- Human immunodeficiency virus
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Clinical Neurology
- Neurology