Cerebrospinal fluid lymphocytes from HIV-infected patients synthesize HIV-specific antibody in vitro

Alberto Amadori; Anita De Rossi; Paolo Gallo; Bruno Tavolato; Luigi Chieco-Bianchi

doi:10.1016/0165-5728(88)90065-3

Cerebrospinal fluid lymphocytes from HIV-infected patients synthesize HIV-specific antibody in vitro

Alberto Amadori, Anita De Rossi, Paolo Gallo, Bruno Tavolato, Luigi Chieco-Bianchi

Istituto Oncologico Veneto

Research output: Contribution to journal › Article

Abstract

Cerebrospinal fluid lymphocytes from six human immunodeficiency virus (HIV)-infected and three seronegative patients were studied for in vitro synthesis of HIV-specific antibody by means of Western blot analysis of lymphocyte culture supernatants. All the HIV-positive subjects showed in vitro production of HIV-specific IgG, regardless of neurological involvement, while no specific antibody synthesis was detected in seronegative individuals. These data provide the first direct evidence that HIV-specific antibody in cerebrospinal fluid is due to intrathecal synthesis.

Original language	English
Pages (from-to)	181-186
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0165-5728(88)90065-3
Publication status	Published - 1988

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Keywords

Acquired immunodeficiency syndrome
Antibody synthesis, in vitro
Cerebrospinal fluid
Human immunodeficiency virus

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Clinical Neurology
Neurology

Cite this

Amadori, A., De Rossi, A., Gallo, P., Tavolato, B., & Chieco-Bianchi, L. (1988). Cerebrospinal fluid lymphocytes from HIV-infected patients synthesize HIV-specific antibody in vitro. Journal of Neuroimmunology, 18(2), 181-186. https://doi.org/10.1016/0165-5728(88)90065-3

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10.1016/0165-5728(88)90065-3