Cerebrospinal fluid lymphocytes from HIV-infected patients synthesize HIV-specific antibody in vitro

Alberto Amadori, Anita De Rossi, Paolo Gallo, Bruno Tavolato, Luigi Chieco-Bianchi

Research output: Contribution to journalArticle

Abstract

Cerebrospinal fluid lymphocytes from six human immunodeficiency virus (HIV)-infected and three seronegative patients were studied for in vitro synthesis of HIV-specific antibody by means of Western blot analysis of lymphocyte culture supernatants. All the HIV-positive subjects showed in vitro production of HIV-specific IgG, regardless of neurological involvement, while no specific antibody synthesis was detected in seronegative individuals. These data provide the first direct evidence that HIV-specific antibody in cerebrospinal fluid is due to intrathecal synthesis.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalJournal of Neuroimmunology
Volume18
Issue number2
DOIs
Publication statusPublished - 1988

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Keywords

  • Acquired immunodeficiency syndrome
  • Antibody synthesis, in vitro
  • Cerebrospinal fluid
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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