Abstract
Purpose: To investigate plasma and cerebrospinal fluid (CSF) concentrations of pentraxin 3 (PTX3), a prototypic long pentraxin protein induced by proinflammatory signals, in subarachnoid hemorrhage (SAH), and its relation with SAH-associated vasospasm. Methods: Serial plasma and CSF samples were collected from 38 consecutive SAH patients admitted to the Neurosurgical Intensive Care. PTX3 concentrations were analyzed in relation to clinical status and clinical vasospasm (defined as neuro-worsening and angiographic confirmation of vessel narrowing). Since neutrophils are an important source of preformed PTX3, myeloperoxidase (MPO) in CSF was measured to assess the correlation with CSF PTX3 and establish whether blood contamination was the determinant of PTX3 increase. Results: PTX3 was elevated in all SAH patients both in plasma and CSF. Acute peak (first 48 h after SAH) CSF PTX3 was significantly higher in patients who later developed vasospasm [median 13.6 (range 2.3-51.9) ng/ml] compared to those who did not [3.2 (0.1-50.5) ng/ml, p = 0.03]. The temporal pattern of CSF PTX3 in patients with vasospasm was triphasic with a peak during the first 48 h after SAH, a subsequent decrease in the following 48-96 h and a secondary significant increase with the occurrence of vasospasm. A loose correlation between CSF PTX3 and MPO was observed (r2 = 0.13), indicating that following SAH there is a brain production of PTX3. Conclusions: Acute increased concentrations of PTX3 in CSF but not in plasma are related to the occurrence of vasospasm, indicating that measurement of CSF PTX3 associated with the clinical evaluation can improve early diagnosis of this complication.
| Original language | English |
|---|---|
| Pages (from-to) | 302-309 |
| Number of pages | 8 |
| Journal | Intensive Care Medicine |
| Volume | 37 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2011 |
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Keywords
- Inflammation
- Pentraxin 3
- Subarachnoid hemorrhage
- Vasospasm
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm. / Zanier, Elisa R.; Brandi, Giovanna; Peri, Giuseppe; Longhi, Luca; Zoerle, Tommaso; Tettamanti, Mauro; Garlanda, Cecilia; Sigurtà, Anna; Valaperta, Serenella; Mantovani, Alberto; De Simoni, Maria Grazia; Stocchetti, Nino.
In: Intensive Care Medicine, Vol. 37, No. 2, 02.2011, p. 302-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrospinal fluid pentraxin 3 early after subarachnoid hemorrhage is associated with vasospasm
AU - Zanier, Elisa R.
AU - Brandi, Giovanna
AU - Peri, Giuseppe
AU - Longhi, Luca
AU - Zoerle, Tommaso
AU - Tettamanti, Mauro
AU - Garlanda, Cecilia
AU - Sigurtà, Anna
AU - Valaperta, Serenella
AU - Mantovani, Alberto
AU - De Simoni, Maria Grazia
AU - Stocchetti, Nino
PY - 2011/2
Y1 - 2011/2
N2 - Purpose: To investigate plasma and cerebrospinal fluid (CSF) concentrations of pentraxin 3 (PTX3), a prototypic long pentraxin protein induced by proinflammatory signals, in subarachnoid hemorrhage (SAH), and its relation with SAH-associated vasospasm. Methods: Serial plasma and CSF samples were collected from 38 consecutive SAH patients admitted to the Neurosurgical Intensive Care. PTX3 concentrations were analyzed in relation to clinical status and clinical vasospasm (defined as neuro-worsening and angiographic confirmation of vessel narrowing). Since neutrophils are an important source of preformed PTX3, myeloperoxidase (MPO) in CSF was measured to assess the correlation with CSF PTX3 and establish whether blood contamination was the determinant of PTX3 increase. Results: PTX3 was elevated in all SAH patients both in plasma and CSF. Acute peak (first 48 h after SAH) CSF PTX3 was significantly higher in patients who later developed vasospasm [median 13.6 (range 2.3-51.9) ng/ml] compared to those who did not [3.2 (0.1-50.5) ng/ml, p = 0.03]. The temporal pattern of CSF PTX3 in patients with vasospasm was triphasic with a peak during the first 48 h after SAH, a subsequent decrease in the following 48-96 h and a secondary significant increase with the occurrence of vasospasm. A loose correlation between CSF PTX3 and MPO was observed (r2 = 0.13), indicating that following SAH there is a brain production of PTX3. Conclusions: Acute increased concentrations of PTX3 in CSF but not in plasma are related to the occurrence of vasospasm, indicating that measurement of CSF PTX3 associated with the clinical evaluation can improve early diagnosis of this complication.
AB - Purpose: To investigate plasma and cerebrospinal fluid (CSF) concentrations of pentraxin 3 (PTX3), a prototypic long pentraxin protein induced by proinflammatory signals, in subarachnoid hemorrhage (SAH), and its relation with SAH-associated vasospasm. Methods: Serial plasma and CSF samples were collected from 38 consecutive SAH patients admitted to the Neurosurgical Intensive Care. PTX3 concentrations were analyzed in relation to clinical status and clinical vasospasm (defined as neuro-worsening and angiographic confirmation of vessel narrowing). Since neutrophils are an important source of preformed PTX3, myeloperoxidase (MPO) in CSF was measured to assess the correlation with CSF PTX3 and establish whether blood contamination was the determinant of PTX3 increase. Results: PTX3 was elevated in all SAH patients both in plasma and CSF. Acute peak (first 48 h after SAH) CSF PTX3 was significantly higher in patients who later developed vasospasm [median 13.6 (range 2.3-51.9) ng/ml] compared to those who did not [3.2 (0.1-50.5) ng/ml, p = 0.03]. The temporal pattern of CSF PTX3 in patients with vasospasm was triphasic with a peak during the first 48 h after SAH, a subsequent decrease in the following 48-96 h and a secondary significant increase with the occurrence of vasospasm. A loose correlation between CSF PTX3 and MPO was observed (r2 = 0.13), indicating that following SAH there is a brain production of PTX3. Conclusions: Acute increased concentrations of PTX3 in CSF but not in plasma are related to the occurrence of vasospasm, indicating that measurement of CSF PTX3 associated with the clinical evaluation can improve early diagnosis of this complication.
KW - Inflammation
KW - Pentraxin 3
KW - Subarachnoid hemorrhage
KW - Vasospasm
UR - http://www.scopus.com/inward/record.url?scp=79953811220&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953811220&partnerID=8YFLogxK
U2 - 10.1007/s00134-010-2075-2
DO - 10.1007/s00134-010-2075-2
M3 - Article
C2 - 21072498
AN - SCOPUS:79953811220
VL - 37
SP - 302
EP - 309
JO - Intensive Care Medicine
JF - Intensive Care Medicine
SN - 0342-4642
IS - 2
ER -