Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt–jakob disease: An international study

Lynne I. Mcguire, Anna Poleggi, Ilaria Poggiolini, Silvia Suardi, Katarina Grznarova, Song Shi, Bart de Vil, Shannon Sarros, Katsuya Satoh, Keding Cheng, Maria Cramm, Graham Fairfoul, Matthias Schmitz, Inga Zerr, Patrick Cras, M. Equestre, Fabrizio Tagliavini, Ryuichiro Atarashi, David Knox, Steven J. CollinsStéphane Haik, Piero Parchi, Maurizio Pocchiari, Alison Green

Research output: Contribution to journalArticle

Abstract

Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt–Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80:160–165.

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalAnnals of Neurology
Volume80
Issue number1
DOIs
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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