Abstract
We assessed cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within gray matter (GM), normal appearing white matter (NAWM) and white matter (WM) lesions in a group of multiple sclerosis (MS) patients. Furthermore, correlations between CBF, CVR and age were investigated. 31 MS patients and 25 healthy controls (HC) were examined on a 1.5 T MRI scanner, using pseudo-continuous arterial spin labeling MRI. MS vs HC CBF and CVR differences were assessed in GM regions of interest (i.e. resting state networks and vascular territories), and within WM. Correlations between CBF/CVR and age were then computed for MS and HC groups. Whereas no significant CBF and CVR differences were observed between MS and HC in any of the considered brain areas, significantly lower CBF was found in WM lesions with respect to NAWM (p < 0.001) in MS patients. Furthermore, CVR was significantly correlated with age in HC, but not in MS patients. The relatively low-grade of inflammation of our MS cohort may be associated with the observed lack of significant CVR differences between MS patients and HC. The loss of correlation between CVR and age in the MS group suggests that CVR may be influenced by MS-related factors.
| Original language | English |
|---|---|
| Journal | Brain Imaging and Behavior |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
Fingerprint
Keywords
- Age
- Arterial spin labeling
- Cerebral blood flow
- Cerebrovascular reactivity
- Multiple sclerosis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Neurology
- Cognitive Neuroscience
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience
Cite this
Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis. / Pelizzari, Laura; Laganà, Maria M.; Baglio, Francesca; Bergsland, Niels; Cecconi, Pietro; Viotti, Stefano; Pugnetti, Luigi; Nemni, Raffaello; Baselli, Giuseppe; Clerici, Mario; Mendozzi, Laura.
In: Brain Imaging and Behavior, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis
AU - Pelizzari, Laura
AU - Laganà, Maria M.
AU - Baglio, Francesca
AU - Bergsland, Niels
AU - Cecconi, Pietro
AU - Viotti, Stefano
AU - Pugnetti, Luigi
AU - Nemni, Raffaello
AU - Baselli, Giuseppe
AU - Clerici, Mario
AU - Mendozzi, Laura
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We assessed cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within gray matter (GM), normal appearing white matter (NAWM) and white matter (WM) lesions in a group of multiple sclerosis (MS) patients. Furthermore, correlations between CBF, CVR and age were investigated. 31 MS patients and 25 healthy controls (HC) were examined on a 1.5 T MRI scanner, using pseudo-continuous arterial spin labeling MRI. MS vs HC CBF and CVR differences were assessed in GM regions of interest (i.e. resting state networks and vascular territories), and within WM. Correlations between CBF/CVR and age were then computed for MS and HC groups. Whereas no significant CBF and CVR differences were observed between MS and HC in any of the considered brain areas, significantly lower CBF was found in WM lesions with respect to NAWM (p < 0.001) in MS patients. Furthermore, CVR was significantly correlated with age in HC, but not in MS patients. The relatively low-grade of inflammation of our MS cohort may be associated with the observed lack of significant CVR differences between MS patients and HC. The loss of correlation between CVR and age in the MS group suggests that CVR may be influenced by MS-related factors.
AB - We assessed cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within gray matter (GM), normal appearing white matter (NAWM) and white matter (WM) lesions in a group of multiple sclerosis (MS) patients. Furthermore, correlations between CBF, CVR and age were investigated. 31 MS patients and 25 healthy controls (HC) were examined on a 1.5 T MRI scanner, using pseudo-continuous arterial spin labeling MRI. MS vs HC CBF and CVR differences were assessed in GM regions of interest (i.e. resting state networks and vascular territories), and within WM. Correlations between CBF/CVR and age were then computed for MS and HC groups. Whereas no significant CBF and CVR differences were observed between MS and HC in any of the considered brain areas, significantly lower CBF was found in WM lesions with respect to NAWM (p < 0.001) in MS patients. Furthermore, CVR was significantly correlated with age in HC, but not in MS patients. The relatively low-grade of inflammation of our MS cohort may be associated with the observed lack of significant CVR differences between MS patients and HC. The loss of correlation between CVR and age in the MS group suggests that CVR may be influenced by MS-related factors.
KW - Age
KW - Arterial spin labeling
KW - Cerebral blood flow
KW - Cerebrovascular reactivity
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85067272676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067272676&partnerID=8YFLogxK
U2 - 10.1007/s11682-019-00132-5
DO - 10.1007/s11682-019-00132-5
M3 - Article
AN - SCOPUS:85067272676
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
SN - 1931-7557
ER -