Cerebrovascular reactivity in migraine with and without aura

Mauro Silvestrini, Maria Matteis, Elio Troisi, Letizia M. Cupini, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review


Abnormal cerebrovascular regulation has been implicated in the pathogenesis of migraine. Our aim in this study was to evaluate cerebrovascular reactivity to different stimulations in migraine with and without aura. Using bilateral transcranial Doppler, the changes of flow velocity during hypercapnia and mental end motor activity were measured in the middle cerebral arteries of 15 controls and 30 patients with migraine with aura (n=15) or without aura (n=15) in an attack-free period. Vascular response to all tests was similar in controls and patients. In patients with unilateral headache, no side-to-side difference was found. These findings suggest that no alteration of cerebrovascular reactivity exists outside attacks in migraine with and without aura. Further studies with transcranial Doppler considering all intragranial vessels and the comparison with other techniques of flow investigation with better regional resolution are needed to confirm these data.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
Issue number1
Publication statusPublished - 1996


  • hemodynamics
  • migraine
  • ultrasonics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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