Using bilateral transcranial Doppler ultrasound, we studied the changes of flow velocity after hypercapnia in the middle cerebral arteries of 10 control subjects and 20 patients (10 symptomatic and 10 asymptomatic) with unilateral severe carotid stenosis. Cerebrovascular reactivity was evaluated with the breath-holding index (BHI). This index (mean value±SD) was significantly lower (p<.001) in the stenotic side of symptomatic patients than in controls, the stenotic side of asymptomatic patients and the normal side of both symptomatic and asymptomatic patients. On the other hand, no significant difference in BHI was detected in controls, on the normal side of symptomatic and asymptomatic patients and the stenotic side of asymptomatic patients. These findings suggest that the study of cerebrovascular reactivity to hypercapnia may be relevant in evaluating the functional effects of carotid stenosis.
|Translated title of the contribution||Cerebrovascular reactivity in patients with carotid stenosis|
|Number of pages||3|
|Journal||Rivista di Neurobiologia|
|Publication status||Published - 1997|
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