Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Antonello Enrico Spinelli, Marco P. Schiariti, Chiara M. Grana, Mahila Ferrari, Marta Cremonesi, Federico Boschi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

Original languageEnglish
Article number050502
JournalJournal of Biomedical Optics
Volume21
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Neurosurgery
brain
Tumors
Brain
tumors
luminescence
Imaging techniques
Luminescence
surgery
charge coupled devices
lenses
prototypes
Charge coupled devices
Image sensors
Surgery
Lenses
electrons
Electrons

Keywords

  • Beta minus radiopharmaceuticals
  • Brain tumor
  • Cerenkov luminescence imaging
  • Neurosurgery
  • Radioluminescence imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery. / Spinelli, Antonello Enrico; Schiariti, Marco P.; Grana, Chiara M.; Ferrari, Mahila; Cremonesi, Marta; Boschi, Federico.

In: Journal of Biomedical Optics, Vol. 21, No. 5, 050502, 01.05.2016.

Research output: Contribution to journalArticle

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