Ceruletide and IRI and blood glucose levels in normal subjects and in diabetics: A controlled study

A. E. Pontiroli, M. Alberetto, G. Vegeto, G. Dossi, C. De Paolis, D. Conte, G. Pozza

Research output: Contribution to journalArticlepeer-review

Abstract

Ceruletide (CRL), a CCK-like synthetic peptide increases insulin (IRI) release in the experimental animal. A similar effect has not been reported in healthy man except during intravenous glucose injection while CRL induced IRI release and hypoglycemia in some patients with insulinoma. We investigated the effect of CRL on IRI release in normal volunteers and the possible interaction between CRL and tolbutamide in adult diabetics under treatment with sulfonylureas. As previously reported in an open study our data show that CRL has no effect on IRI release and blood glucose levels in normal volunteers, its effect being superimposable to placebo.

Original languageEnglish
Pages (from-to)329-330
Number of pages2
JournalHormone and Metabolic Research
Volume14
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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