Ceruletide (CRL), a CCK-like synthetic peptide increases insulin (IRI) release in the experimental animal. A similar effect has not been reported in healthy man except during intravenous glucose injection while CRL induced IRI release and hypoglycemia in some patients with insulinoma. We investigated the effect of CRL on IRI release in normal volunteers and the possible interaction between CRL and tolbutamide in adult diabetics under treatment with sulfonylureas. As previously reported in an open study our data show that CRL has no effect on IRI release and blood glucose levels in normal volunteers, its effect being superimposable to placebo.
|Number of pages||2|
|Journal||Hormone and Metabolic Research|
|Publication status||Published - 1982|
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