Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times

C. Clemente, F. Russo, M. G. Caruso, M. Giangrande, G. Fanizza, A. Di Leo

Research output: Contribution to journalArticle


The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens.

Original languageEnglish
Pages (from-to)191-193
Number of pages3
JournalHormone and Metabolic Research
Issue number4
Publication statusPublished - 1992



  • ceruloplasmin
  • circadian rhythm
  • estrogen therapy
  • sex steroid hormones

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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