Ceruloplasmin/Transferrin system is related to clinical status in acute stroke

Claudia Altamura, Rosanna Squitti, Patrizio Pasqualetti, Chiara Gaudino, Paola Palazzo, Francesco Tibuzzi, Domenico Lupoi, Maurizio Cortesi, Paolo Maria Rossini, Fabrizio Vernieri

Research output: Contribution to journalArticle

Abstract

Background and Purpose - In acute stroke, Iron (Fe) may amplify reperfusion injury by catalyzing the conversion of superoxide and hydrogen peroxide into highly reactive radicals. Transferrin (Tf) is the main protein regulating Fe homeostasis, whereas Ceruplasmin (CP) is a circulating ferroxidase enzyme able to oxidize ferrous ions to less toxic ferric forms. This study aims at investigating whether CP, Copper (Cu), Tf, and Fe play a role in the pathophysiology of acute stroke. Methods - We enrolled 35 acute stroke patients and 44 controls. All patients underwent: neurological examination assessed by National Institutes of Health Stroke Scale (NIHSS), ultrasound evaluation of carotid atherosclerosis, brain MRI to quantify ischemic lesion volume and measurement of serum levels of CP, Cu, Tf, Fe, hydro-peroxides, and Total plasmatic antioxidant capacity. Results - In patients, NIHSS scores were associated with Tf (r=-0.48, P=0.004), hydro-peroxides (r=0.34, P=0.046), CP (r=0.43, P=0.012), and lesion volume (r=0.50, P=0.004). Lesion volume was inversely associated with Tf (r= -0.44, P=0.012). CP and hydro-peroxides were also largely related (r=0.81, P

Original languageEnglish
Pages (from-to)1282-1288
Number of pages7
JournalStroke
Volume40
Issue number4
DOIs
Publication statusPublished - Apr 1 2009

Keywords

  • Acute stroke
  • Ceruloplasmin
  • Copper
  • Iron
  • Transform

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Medicine(all)

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    Altamura, C., Squitti, R., Pasqualetti, P., Gaudino, C., Palazzo, P., Tibuzzi, F., Lupoi, D., Cortesi, M., Rossini, P. M., & Vernieri, F. (2009). Ceruloplasmin/Transferrin system is related to clinical status in acute stroke. Stroke, 40(4), 1282-1288. https://doi.org/10.1161/STROKEAHA.108.536714