TY - JOUR
T1 - Ceruloplasmin/Transferrin system is related to clinical status in acute stroke
AU - Altamura, Claudia
AU - Squitti, Rosanna
AU - Pasqualetti, Patrizio
AU - Gaudino, Chiara
AU - Palazzo, Paola
AU - Tibuzzi, Francesco
AU - Lupoi, Domenico
AU - Cortesi, Maurizio
AU - Rossini, Paolo Maria
AU - Vernieri, Fabrizio
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Background and Purpose - In acute stroke, Iron (Fe) may amplify reperfusion injury by catalyzing the conversion of superoxide and hydrogen peroxide into highly reactive radicals. Transferrin (Tf) is the main protein regulating Fe homeostasis, whereas Ceruplasmin (CP) is a circulating ferroxidase enzyme able to oxidize ferrous ions to less toxic ferric forms. This study aims at investigating whether CP, Copper (Cu), Tf, and Fe play a role in the pathophysiology of acute stroke. Methods - We enrolled 35 acute stroke patients and 44 controls. All patients underwent: neurological examination assessed by National Institutes of Health Stroke Scale (NIHSS), ultrasound evaluation of carotid atherosclerosis, brain MRI to quantify ischemic lesion volume and measurement of serum levels of CP, Cu, Tf, Fe, hydro-peroxides, and Total plasmatic antioxidant capacity. Results - In patients, NIHSS scores were associated with Tf (r=-0.48, P=0.004), hydro-peroxides (r=0.34, P=0.046), CP (r=0.43, P=0.012), and lesion volume (r=0.50, P=0.004). Lesion volume was inversely associated with Tf (r= -0.44, P=0.012). CP and hydro-peroxides were also largely related (r=0.81, P
AB - Background and Purpose - In acute stroke, Iron (Fe) may amplify reperfusion injury by catalyzing the conversion of superoxide and hydrogen peroxide into highly reactive radicals. Transferrin (Tf) is the main protein regulating Fe homeostasis, whereas Ceruplasmin (CP) is a circulating ferroxidase enzyme able to oxidize ferrous ions to less toxic ferric forms. This study aims at investigating whether CP, Copper (Cu), Tf, and Fe play a role in the pathophysiology of acute stroke. Methods - We enrolled 35 acute stroke patients and 44 controls. All patients underwent: neurological examination assessed by National Institutes of Health Stroke Scale (NIHSS), ultrasound evaluation of carotid atherosclerosis, brain MRI to quantify ischemic lesion volume and measurement of serum levels of CP, Cu, Tf, Fe, hydro-peroxides, and Total plasmatic antioxidant capacity. Results - In patients, NIHSS scores were associated with Tf (r=-0.48, P=0.004), hydro-peroxides (r=0.34, P=0.046), CP (r=0.43, P=0.012), and lesion volume (r=0.50, P=0.004). Lesion volume was inversely associated with Tf (r= -0.44, P=0.012). CP and hydro-peroxides were also largely related (r=0.81, P
KW - Acute stroke
KW - Ceruloplasmin
KW - Copper
KW - Iron
KW - Transform
UR - http://www.scopus.com/inward/record.url?scp=65249134321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65249134321&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.108.536714
DO - 10.1161/STROKEAHA.108.536714
M3 - Article
C2 - 19228837
AN - SCOPUS:65249134321
VL - 40
SP - 1282
EP - 1288
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 4
ER -