Cervical cancer screening by high risk HPV testing in routine practice: Results at one year recall of high risk HPV-positive and cytology-negative women

Annarosa Del Mistro, Helena Frayle, Antonio Ferro, Susanna Callegaro, Annamaria Del Sole, Anna Stomeo, Emanuela Cirillo, Chiara Fedato, Silvana Pagni, Luisa Barzon, Manuel Zorzi, Manuel Zorzi, Chiara Fedato, Susanna Baracco, Carla Cogo, Helena Frayle, Martina Rizzi, Lorena Baboci, Luisa Barzon, Silvana PagniSara Masiero, Giorgio Palù, Antonio Ferro, Alessandra Bertazzo, Angelo Farruggio, Patrizia Cocco, Paolo Lucio Tumaini, Pierfrancesco Gerace, Fausta Ortu, Susanna Callegaro, Loretta Borgato, Renata Maso, Patrizio Bo, Fiorenza Peron, Annamaria Del Sole, Remigia Spitti, Elena Astolfi, Enrico Di Mambro, Nicola Paolo Saliani, Anna Stomeo, Lorenza Gallo, Laura Borghi, Rita Buoso, Ivana Simoncello, Emanuela Cirillo, GianLibero L. Onnis, Giovanni Nardelli, Daria Minucci, Egle Insacco, Mario Matteucci, Gabriella Braggion

Research output: Contribution to journalArticlepeer-review


Objective: Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women's compliance with and the performance of this strategy in a routine setting. Setting: Five cervical service screening programmes in North-East Italy. Methods: Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing. Results: Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9% detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat. Conclusions: Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalJournal of Medical Screening
Issue number1
Publication statusPublished - 2014


  • Follow-up
  • HPV
  • Organized screening
  • Triage

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Policy


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