Screening cervicovaginale con test HPV-DNA primario nella ASL 2 savonese: uno studio di popolazione

Translated title of the contribution: Cervical cancer screening with primary HPV-DNA test in the Local Health Authority 2 of Savona (Liguria Region, Northern Italy): a population-based study

Elisabetta Depetrini, Luigina Bonelli, Silvia Ardoino, Maria Cristina Cirucca, Renzo Contin, Damiana De Leonardis, Veronica Errigo, Andrea Lugani, Alessandra Franco, Alessandro Pastorino, Giuliano Carrozzi, Ezio Venturino

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: to describe the performance and the impact on the population coverage of a population-based organised screening programme with primary HPV-DNA test.

DESIGN: population-based cohort study.

SETTING AND PARTICIPANTS: organised screening programme for women aged 30-64 years.

MAIN OUTCOME MEASURES: coverage of the target population with Pap test and HPV-DNA test, compliance to invitation, positivity at HPV-DNA testing, proportion of positive Pap test (squamous cells of undetermined significance or more severe, ASC-US+), referral for colposcopy, positive predictive value (PPV) of the cytology triage for grade-2 or more severe intraepithelial neoplasia (CIN2+), detection rate of CIN2+. Regarding coverage, seasonally adjusted trends of the PASSI surveillance from 2008 to 2014 were analysed. To evaluate performance, data of the information screening system were used.

RESULTS: from December 2011 to December 2014, 48,852 women were invited for screening and 22,991 participated (48.4%); in addition, 968 women spontaneously participated in the programme, achieving a total of 23,959 screened women. The HPV test resulted positive for 2,000 women (8.4%). After triage 1,049 women were referred for colposcopy because of ASC-US+ (No. 968) or inadequate result (No. 81). The compliance at 12 months retesting among women with positive HPV test and negative triage was 79.3%, and the HPV positive rate was 60.4%. In the whole, 1,322 women were referred for colposcopy (5.5%) and 1,221 were actually tested. The overall detection rate for CIN2+ was 6.2/1,000. From 2011 to 2014, spontaneous Pap tests passed from 7,461/year to 2,491/year; the test coverage achieved a positive trend and it settles in recent years to 83%, including 43% of HPV-DNA.

CONCLUSIONS: compliance to screening of invited women was satisfactory compared to previous experiences in Liguria Region (Northern Italy). Performance indicators confirm what was observed in other Italian experiences.

Translated title of the contributionCervical cancer screening with primary HPV-DNA test in the Local Health Authority 2 of Savona (Liguria Region, Northern Italy): a population-based study
Original languageItalian
Pages (from-to)171-8
Number of pages8
JournalEpidemiologia e prevenzione
Volume40
Issue number3-4
DOIs
Publication statusPublished - Jul 22 2016

Keywords

  • English Abstract
  • Journal Article

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