Abstract
Objective: To present the results of the first and second round human papilloma virus (HPV)-based screening programme in the Umbria region after three years. Methods: From August 2010 to November 2011, the entire female population aged 35-64 in a local health district was invited for HPV testing (HPV-DNA cobas4800 on a liquid-based cytology sample). HPV-negative women were re-invited after three years. For HPV-positive women, a slide was prepared and interpreted. Positive cytologies were referred to colposcopy; negatives were referred to repeat HPV after one year. If HPV was persistently positive, women were referred to colposcopy; if negative, to normal screening. Indicators of the first and second round are compared with those of cytology screening in the same area in the preceding three years. Results: Participation was 56.5%, the same as cytology (56.6%). HPV-positivity was 6.4% (396/6272), cytology triage positivity was 35.6%; 251 cytology negative women were referred to one-year HPV retesting, 84.1% complied, and 55.5% were positive. Total colposcopy referral was 4.1%, and for cytology 1%. The detection rate for cervical intraepithelial neoplasia grade 2 or more severe was 10%, compared with 3.7% using cytology. After three years, HPV-positivity was 3.4% (129/3831), overall colposcopy referral was 2.3% (most at one-year follow-up), and detection rate was 0.5/1000. Conclusions: The first round detection rate was more than twice that of cytology screening, while colposcopy referral increased fourfold. At the second round, the detection rate decreased dramatically, showing that longer interval and more conservative protocols are needed.
| Original language | English |
|---|---|
| Pages (from-to) | 153-162 |
| Number of pages | 10 |
| Journal | Journal of Medical Screening |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- Cervical cancer
- Human papilloma virus
- Screening
ASJC Scopus subject areas
- Health Policy
- Public Health, Environmental and Occupational Health
Cite this
Cervical human papilloma virus (HPV) DNA primary screening test : Results of a population-based screening programme in central Italy. / Passamonti, Basilio; Gustinucci, Daniela; Giorgi Rossi, Paolo; Cesarini, Elena; Bulletti, Simonetta; Carlani, Angela; Martinelli, Nadia; Broccolini, Massimo; D’Angelo, Valentina; D’Amico, Maria Rosaria; Di Dato, Eugenio; Galeazzi, Paola; Malaspina, Morena; Spita, Nicoletta; Tintori, Beatrice; Giaimo, Maria Donata.
In: Journal of Medical Screening, Vol. 24, No. 3, 2017, p. 153-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cervical human papilloma virus (HPV) DNA primary screening test
T2 - Results of a population-based screening programme in central Italy
AU - Passamonti, Basilio
AU - Gustinucci, Daniela
AU - Giorgi Rossi, Paolo
AU - Cesarini, Elena
AU - Bulletti, Simonetta
AU - Carlani, Angela
AU - Martinelli, Nadia
AU - Broccolini, Massimo
AU - D’Angelo, Valentina
AU - D’Amico, Maria Rosaria
AU - Di Dato, Eugenio
AU - Galeazzi, Paola
AU - Malaspina, Morena
AU - Spita, Nicoletta
AU - Tintori, Beatrice
AU - Giaimo, Maria Donata
PY - 2017
Y1 - 2017
N2 - Objective: To present the results of the first and second round human papilloma virus (HPV)-based screening programme in the Umbria region after three years. Methods: From August 2010 to November 2011, the entire female population aged 35-64 in a local health district was invited for HPV testing (HPV-DNA cobas4800 on a liquid-based cytology sample). HPV-negative women were re-invited after three years. For HPV-positive women, a slide was prepared and interpreted. Positive cytologies were referred to colposcopy; negatives were referred to repeat HPV after one year. If HPV was persistently positive, women were referred to colposcopy; if negative, to normal screening. Indicators of the first and second round are compared with those of cytology screening in the same area in the preceding three years. Results: Participation was 56.5%, the same as cytology (56.6%). HPV-positivity was 6.4% (396/6272), cytology triage positivity was 35.6%; 251 cytology negative women were referred to one-year HPV retesting, 84.1% complied, and 55.5% were positive. Total colposcopy referral was 4.1%, and for cytology 1%. The detection rate for cervical intraepithelial neoplasia grade 2 or more severe was 10%, compared with 3.7% using cytology. After three years, HPV-positivity was 3.4% (129/3831), overall colposcopy referral was 2.3% (most at one-year follow-up), and detection rate was 0.5/1000. Conclusions: The first round detection rate was more than twice that of cytology screening, while colposcopy referral increased fourfold. At the second round, the detection rate decreased dramatically, showing that longer interval and more conservative protocols are needed.
AB - Objective: To present the results of the first and second round human papilloma virus (HPV)-based screening programme in the Umbria region after three years. Methods: From August 2010 to November 2011, the entire female population aged 35-64 in a local health district was invited for HPV testing (HPV-DNA cobas4800 on a liquid-based cytology sample). HPV-negative women were re-invited after three years. For HPV-positive women, a slide was prepared and interpreted. Positive cytologies were referred to colposcopy; negatives were referred to repeat HPV after one year. If HPV was persistently positive, women were referred to colposcopy; if negative, to normal screening. Indicators of the first and second round are compared with those of cytology screening in the same area in the preceding three years. Results: Participation was 56.5%, the same as cytology (56.6%). HPV-positivity was 6.4% (396/6272), cytology triage positivity was 35.6%; 251 cytology negative women were referred to one-year HPV retesting, 84.1% complied, and 55.5% were positive. Total colposcopy referral was 4.1%, and for cytology 1%. The detection rate for cervical intraepithelial neoplasia grade 2 or more severe was 10%, compared with 3.7% using cytology. After three years, HPV-positivity was 3.4% (129/3831), overall colposcopy referral was 2.3% (most at one-year follow-up), and detection rate was 0.5/1000. Conclusions: The first round detection rate was more than twice that of cytology screening, while colposcopy referral increased fourfold. At the second round, the detection rate decreased dramatically, showing that longer interval and more conservative protocols are needed.
KW - Cervical cancer
KW - Human papilloma virus
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=85028542075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028542075&partnerID=8YFLogxK
U2 - 10.1177/0969141316663580
DO - 10.1177/0969141316663580
M3 - Article
AN - SCOPUS:85028542075
VL - 24
SP - 153
EP - 162
JO - Journal of Medical Screening
JF - Journal of Medical Screening
SN - 0969-1413
IS - 3
ER -