Cervical intraepithelial neoplasia (CIN) in pregnancy: The state of the art

M. Origoni, S. Salvatore, A. Perino, G. Cucinella, M. Candiani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

OBJECTIVES: Cervical cancer is the most commonly diagnosed malignancy in pregnancy and cervical screening should be accordingly performed in this particular situation. Occurrence of a preneoplastic cervical disease in pregnancy has for a long time represented a challenge for the clinician, both in terms of diagnostic accuracy, treatment options and risk of obstetrical complications. For these reasons, lack of uniformity in diagnosis and management is still commonly observed and the need for evidencEbased clarifications is strongly required. Consistently with the literature evidences and accordingly with international guidelines, this review aim to overview the most significant aspects of the issue and trace simple and practical indications for an evidencebased correct workout and management of these conditions. MATERIALS AND METHODS: The most significative and focused-on results from literature as well as recent international guidelines have been considered and summarized in order to clarify the key-points of the topic; epidemiology, pathophysiology, natural history, treatment modalities and procedurErelated risks have been approached and discussed. RESULTS: Risk factors, prevalence and progression rate of cervical intraepithelial neoplasia in pregnancy are comparable to those observed in non-pregnant patients; thus, pregnancy does not have to be considered a condition at higher risk. Cytology, histology and colposcopic patterns must be evaluated by experienced professionals because of pregnancy-induced modifications that can lead to misinterpretations. Each diagnostic step should be directed to exclusion of invasive cervical cancer. CONCLUSIONS: Once invasive cancer has been excluded through a comprehensive diagnostic workout, treatment of cervical intraepithelial neoplasia can be safely deferred after delivery.

Original languageEnglish
Pages (from-to)851-860
Number of pages10
JournalEuropean Review for Medical and Pharmacological Sciences
Volume18
Issue number6
Publication statusPublished - 2014

Fingerprint

Cervical Intraepithelial Neoplasia
Pregnancy
Uterine Cervical Neoplasms
Guidelines
Natural History
Cell Biology
Neoplasms
Histology
Epidemiology
Therapeutics

Keywords

  • Cervical Intraepithelial Neoplasia
  • CIN
  • Guidelines
  • Pregnancy
  • Screening

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

Cervical intraepithelial neoplasia (CIN) in pregnancy : The state of the art. / Origoni, M.; Salvatore, S.; Perino, A.; Cucinella, G.; Candiani, M.

In: European Review for Medical and Pharmacological Sciences, Vol. 18, No. 6, 2014, p. 851-860.

Research output: Contribution to journalArticle

Origoni, M. ; Salvatore, S. ; Perino, A. ; Cucinella, G. ; Candiani, M. / Cervical intraepithelial neoplasia (CIN) in pregnancy : The state of the art. In: European Review for Medical and Pharmacological Sciences. 2014 ; Vol. 18, No. 6. pp. 851-860.
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