IgA secretorie del muco cervicale in condizioni neoplastiche e non neoplastiche della cervice uterina

Translated title of the contribution: Cervical mucus secretory IgA in non neoplastic and neoplastic conditions of the uterine cervix

A. Casamassima, L. Marinaccio, F. Fanciullo, M. Correale, S. Petroni, S. Wiesel, G. Simone, A. Marzullo, M. A. Caponio, G. Falco

Research output: Contribution to journalArticlepeer-review

Abstract

In 39 women affected by cervical intraepithelial neoplasia (CIN) concentration of the cervical mucus secretory IgA (sIgA) was significantly higher than in 414 controls matched for age, reproductive status and smoking habit (196 healthy women; 109 with "specific" and "aspecific" cervicitis or cervico-vaginitis; 51 with benign epithelial disorders of the cervix; 40 with adenomatous cervical polyp and 18 with early invasive esocervical squamous carcinoma). CIN carried the highest proportion of cases with sIgA detectable or beyond the cut-off value and sIgA concentration was inversely related to CIN grade. Present data confirm our preliminary investigation on the cervical total IgA and explain that any increased levels of these IgA are induced by the secretory and not sieric fraction of this immunoglobulin. We still don't know the exact meaning and value of the present results. It is only possible to suppose that they are the expression of a vigorous local immune activation adverse to CIN, which is elevated for as long as the architecture of cervical glandular epithelia is preserved.

Translated title of the contributionCervical mucus secretory IgA in non neoplastic and neoplastic conditions of the uterine cervix
Original languageItalian
Pages (from-to)7-12
Number of pages6
JournalMinerva Ginecologica
Volume49
Issue number1-2
Publication statusPublished - Jan 1997

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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