Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia

Luca Giannella, Sonia Prandi, Simone Giulini, Kabala Mfuta, Barbara Torrini, Fausto Boselli

Research output: Contribution to journalArticle

Abstract

Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ratio (OR) = 5.16], high-grade squamous intraepithelial lesion cytology (OR = 16.19), condom non-use (OR = 4.28), cervical NOx levels ≤99.9 μmol/L (OR = 16.62), more than four lifetime male sexual partners (OR = 10.56), and age at first coitus of ≤15 years old (OR = 3.54). This combined model had a sensitivity of 86.49 %, a specificity of 90.74 %, a positive predictive value of 64.0 %, and a negative predictive value of 97.2 %. Conclusions: In the present sample, high-grade CIN associated with decreased cervical NOx levels. Thus, along with some clinical variables, cervical NOx levels may be an additional marker of cervical dysplasia.

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume288
Issue number5
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Cervical Intraepithelial Neoplasia
Nitric Oxide
Odds Ratio
Uterine Cervical Dysplasia
Biopsy
Papanicolaou Test
Colposcopy
Sexual Partners
Coitus
Condoms
ROC Curve
Cell Biology
Multivariate Analysis

Keywords

  • Cervical intraepithelial neoplasia
  • Clinical variables
  • Nitric oxide
  • Prediction model

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia. / Giannella, Luca; Prandi, Sonia; Giulini, Simone; Mfuta, Kabala; Torrini, Barbara; Boselli, Fausto.

In: Archives of Gynecology and Obstetrics, Vol. 288, No. 5, 11.2013, p. 1095-1100.

Research output: Contribution to journalArticle

Giannella, Luca ; Prandi, Sonia ; Giulini, Simone ; Mfuta, Kabala ; Torrini, Barbara ; Boselli, Fausto. / Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia. In: Archives of Gynecology and Obstetrics. 2013 ; Vol. 288, No. 5. pp. 1095-1100.
@article{353a25cff88f494386e75fad9271078e,
title = "Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia",
abstract = "Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ratio (OR) = 5.16], high-grade squamous intraepithelial lesion cytology (OR = 16.19), condom non-use (OR = 4.28), cervical NOx levels ≤99.9 μmol/L (OR = 16.62), more than four lifetime male sexual partners (OR = 10.56), and age at first coitus of ≤15 years old (OR = 3.54). This combined model had a sensitivity of 86.49 {\%}, a specificity of 90.74 {\%}, a positive predictive value of 64.0 {\%}, and a negative predictive value of 97.2 {\%}. Conclusions: In the present sample, high-grade CIN associated with decreased cervical NOx levels. Thus, along with some clinical variables, cervical NOx levels may be an additional marker of cervical dysplasia.",
keywords = "Cervical intraepithelial neoplasia, Clinical variables, Nitric oxide, Prediction model",
author = "Luca Giannella and Sonia Prandi and Simone Giulini and Kabala Mfuta and Barbara Torrini and Fausto Boselli",
year = "2013",
month = "11",
doi = "10.1007/s00404-013-2850-8",
language = "English",
volume = "288",
pages = "1095--1100",
journal = "Archives of Gynecology",
issn = "0170-9925",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - Cervical nitric oxide metabolite levels and clinical variables as predictive factors of high-grade cervical intraepithelial neoplasia

AU - Giannella, Luca

AU - Prandi, Sonia

AU - Giulini, Simone

AU - Mfuta, Kabala

AU - Torrini, Barbara

AU - Boselli, Fausto

PY - 2013/11

Y1 - 2013/11

N2 - Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ratio (OR) = 5.16], high-grade squamous intraepithelial lesion cytology (OR = 16.19), condom non-use (OR = 4.28), cervical NOx levels ≤99.9 μmol/L (OR = 16.62), more than four lifetime male sexual partners (OR = 10.56), and age at first coitus of ≤15 years old (OR = 3.54). This combined model had a sensitivity of 86.49 %, a specificity of 90.74 %, a positive predictive value of 64.0 %, and a negative predictive value of 97.2 %. Conclusions: In the present sample, high-grade CIN associated with decreased cervical NOx levels. Thus, along with some clinical variables, cervical NOx levels may be an additional marker of cervical dysplasia.

AB - Purpose: To create a prediction model of high-grade cervical intraepithelial neoplasia (CIN) based on clinical variables and the cervical nitric oxide metabolite (NOx) levels of study participants. Methods: This comparative study included 694 women undergoing colposcopy due to abnormal pap smear results. On the basis of the cervical biopsy results, the women were divided into the ≤CIN 1 or CIN 2-3 group. The two groups were compared in terms of cervical NOx levels and clinical variables. Univariate, multivariate, and receiver-operating characteristic curve analysis were performed. Results: Multivariate analysis showed that CIN 2-3 associated with more than two cervical biopsies [odds ratio (OR) = 5.16], high-grade squamous intraepithelial lesion cytology (OR = 16.19), condom non-use (OR = 4.28), cervical NOx levels ≤99.9 μmol/L (OR = 16.62), more than four lifetime male sexual partners (OR = 10.56), and age at first coitus of ≤15 years old (OR = 3.54). This combined model had a sensitivity of 86.49 %, a specificity of 90.74 %, a positive predictive value of 64.0 %, and a negative predictive value of 97.2 %. Conclusions: In the present sample, high-grade CIN associated with decreased cervical NOx levels. Thus, along with some clinical variables, cervical NOx levels may be an additional marker of cervical dysplasia.

KW - Cervical intraepithelial neoplasia

KW - Clinical variables

KW - Nitric oxide

KW - Prediction model

UR - http://www.scopus.com/inward/record.url?scp=84886087166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886087166&partnerID=8YFLogxK

U2 - 10.1007/s00404-013-2850-8

DO - 10.1007/s00404-013-2850-8

M3 - Article

C2 - 23595585

AN - SCOPUS:84886087166

VL - 288

SP - 1095

EP - 1100

JO - Archives of Gynecology

JF - Archives of Gynecology

SN - 0170-9925

IS - 5

ER -