Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: A pilot study

Marco Benazzo, Salvatore Leonardi, Angelo Corsico, Amelia Licari, Michele Miraglia Del Giudice, Diego G. Peroni, Carmelo Salpietro, Gian Luigi Marseglia, Giorgio Ciprandi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aim: Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continu-ous cetirizine treatment in a group of Italian children with SAR. Methods: Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment. Results: Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both). Conclusions: The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe.

Original languageEnglish
Article numbere2021003
JournalActa Biomedica
Volume92
Issue number1
DOIs
Publication statusPublished - Mar 5 2021

Keywords

  • Cetirizine
  • Children
  • Quality of life
  • Seasonal allergic rhinitis
  • Symptoms

ASJC Scopus subject areas

  • Medicine(all)

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