Cetirizine reduces conjunctival nonspecific hyperreactivity in children with mite allergy

M. Tosca, G. Ciprandi, G. Passalacqua, G. W. Canonica

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

As mite allergy is characterized by a continuous allergen exposure, persistent inflammation is always detectable even during symptomless periods. It has been reported that mite allergic patients present a nonspecific hyperreactivity to different stimuli, including hyperosmolar solution. Since it has been reported previously that cetirizine is able to reduce minimal persistent inflammation due to mite allergy, the aim of the study was to investigate the effect of cetirizine on nonspecific conjunctival hyperreactivity. Twenty children with mite allergy were studied; two hyperosmolar conjunctival challenges were performed before and after cetirizine or placebo treatment, lasting one week. Patients treated with cetirizine showed a significant reduction in nonspecific conjunctival hyperreactivity compared to the placebo group (p <0.05). In conclusion, cetirizine was able to reduce nonspecific hyperreactivity related to allergic inflammation.

Fingerprint

Cetirizine
Mites
Hypersensitivity
Inflammation
Placebos
Allergens

Keywords

  • Cetirizine
  • Conjunctival challenge
  • Hyperosmolar solution
  • Minimal persistent inflammation
  • Mite allergy
  • Nonspecific hyperreactivity

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

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title = "Cetirizine reduces conjunctival nonspecific hyperreactivity in children with mite allergy",
abstract = "As mite allergy is characterized by a continuous allergen exposure, persistent inflammation is always detectable even during symptomless periods. It has been reported that mite allergic patients present a nonspecific hyperreactivity to different stimuli, including hyperosmolar solution. Since it has been reported previously that cetirizine is able to reduce minimal persistent inflammation due to mite allergy, the aim of the study was to investigate the effect of cetirizine on nonspecific conjunctival hyperreactivity. Twenty children with mite allergy were studied; two hyperosmolar conjunctival challenges were performed before and after cetirizine or placebo treatment, lasting one week. Patients treated with cetirizine showed a significant reduction in nonspecific conjunctival hyperreactivity compared to the placebo group (p <0.05). In conclusion, cetirizine was able to reduce nonspecific hyperreactivity related to allergic inflammation.",
keywords = "Cetirizine, Conjunctival challenge, Hyperosmolar solution, Minimal persistent inflammation, Mite allergy, Nonspecific hyperreactivity",
author = "M. Tosca and G. Ciprandi and G. Passalacqua and Canonica, {G. W.}",
year = "1998",
language = "English",
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T1 - Cetirizine reduces conjunctival nonspecific hyperreactivity in children with mite allergy

AU - Tosca, M.

AU - Ciprandi, G.

AU - Passalacqua, G.

AU - Canonica, G. W.

PY - 1998

Y1 - 1998

N2 - As mite allergy is characterized by a continuous allergen exposure, persistent inflammation is always detectable even during symptomless periods. It has been reported that mite allergic patients present a nonspecific hyperreactivity to different stimuli, including hyperosmolar solution. Since it has been reported previously that cetirizine is able to reduce minimal persistent inflammation due to mite allergy, the aim of the study was to investigate the effect of cetirizine on nonspecific conjunctival hyperreactivity. Twenty children with mite allergy were studied; two hyperosmolar conjunctival challenges were performed before and after cetirizine or placebo treatment, lasting one week. Patients treated with cetirizine showed a significant reduction in nonspecific conjunctival hyperreactivity compared to the placebo group (p <0.05). In conclusion, cetirizine was able to reduce nonspecific hyperreactivity related to allergic inflammation.

AB - As mite allergy is characterized by a continuous allergen exposure, persistent inflammation is always detectable even during symptomless periods. It has been reported that mite allergic patients present a nonspecific hyperreactivity to different stimuli, including hyperosmolar solution. Since it has been reported previously that cetirizine is able to reduce minimal persistent inflammation due to mite allergy, the aim of the study was to investigate the effect of cetirizine on nonspecific conjunctival hyperreactivity. Twenty children with mite allergy were studied; two hyperosmolar conjunctival challenges were performed before and after cetirizine or placebo treatment, lasting one week. Patients treated with cetirizine showed a significant reduction in nonspecific conjunctival hyperreactivity compared to the placebo group (p <0.05). In conclusion, cetirizine was able to reduce nonspecific hyperreactivity related to allergic inflammation.

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KW - Minimal persistent inflammation

KW - Mite allergy

KW - Nonspecific hyperreactivity

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