Abstract
Cetirizine has been demonstrated able of reducing nasal inflammatory infiltration in children with allergic rhinitis and cytokine production in in vitro studies. The aim of this double-blind, placebo-controlled, and randomized study was to evaluate cytokine pattern and inflammatory cells in children with perennial allergic rhinitis, before and after treatment with cetirizine or placebo. Twenty children with perennial allergic rhinitis were evaluated, 13 males and 7 females (mean age 13.4 years). Inflammatory cells and cytokines were evaluated by scraping and nasal lavage, before and after 2-weeks administration of cetirizine or placebo. IL4 and IL8 were measured by immunoassay and inflammatory cells were counted by conventional staining. Cetirizine treatment induced a significant decrease of IL4 (p
| Original language | English |
|---|---|
| Pages (from-to) | 237-240 |
| Number of pages | 4 |
| Journal | European Annals of Allergy and Clinical Immunology |
| Volume | 36 |
| Issue number | 6 |
| Publication status | Published - Jun 2004 |
Keywords
- Cetirizine
- Children
- Cytokines
- Inflammatory cells
- Perennial allergic rhinitis
ASJC Scopus subject areas
- Immunology and Allergy