Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis

G. Ciprandi, M. A. Tosca, M. Milanese, V. Ricca

Research output: Contribution to journalArticlepeer-review

Abstract

Cetirizine has been demonstrated able of reducing nasal inflammatory infiltration in children with allergic rhinitis and cytokine production in in vitro studies. The aim of this double-blind, placebo-controlled, and randomized study was to evaluate cytokine pattern and inflammatory cells in children with perennial allergic rhinitis, before and after treatment with cetirizine or placebo. Twenty children with perennial allergic rhinitis were evaluated, 13 males and 7 females (mean age 13.4 years). Inflammatory cells and cytokines were evaluated by scraping and nasal lavage, before and after 2-weeks administration of cetirizine or placebo. IL4 and IL8 were measured by immunoassay and inflammatory cells were counted by conventional staining. Cetirizine treatment induced a significant decrease of IL4 (p

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalEuropean Annals of Allergy and Clinical Immunology
Volume36
Issue number6
Publication statusPublished - Jun 2004

Keywords

  • Cetirizine
  • Children
  • Cytokines
  • Inflammatory cells
  • Perennial allergic rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

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