Cetuximab in non-small-cell lung cancer

Research output: Contribution to journalArticle

Abstract

Cetuximab is a chimeric human-mouse anti-EGF receptor monoclonal antibody. In Phase I studies, no dose-limiting toxicities were observed with cetuximab as a single agent or combined with chemotherapy; pharmacokinetic and pharmacodynamic analyses supported 250 mg/m 2 weekly administration. Skin toxicity, diarrhea and fatigue were the most common toxicities. The positive results obtained in Phase II trials in patients with advanced non-small-cell lung cancer prompted two randomized Phase III trials evaluating cetuximab in addition to first-line chemotherapy. Both trials showed a small benefit in overall survival for the experimental treatment, which was considered insufficient by the EMA for marketing approval. However, a subgroup analysis of the FLEX Phase III trial recently demonstrated a larger survival benefit from the experimental treatment in patients with high immunohistochemical EGF receptor expression. This finding, if confirmed prospectively, could represent a new opportunity for positioning cetuximab into the standard treatment of advanced non-small-cell lung carcinoma.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalExpert Review of Anticancer Therapy
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • cetuximab
  • clinical trials
  • EGFR
  • NSCLC

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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