CGF Treatment of Leg Ulcers: a Randomized Controlled Trial

Bruno Amato, Michele Angelo Farina, Silvana Campisi, Marino Ciliberti, Vincenzo Di Donna, Anna Florio, Antonino Grasso, Rosario Miranda, Francesco Pompeo, Eleonora Farina, Raffaele Serra, Roberto Cirocchi, Francesca Calemma, Aldo Rocca, Rita Compagna

Research output: Contribution to journalArticlepeer-review


Background: Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.

Aim: The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.

Methods: Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.

Results: The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.

Conclusions: These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.

Original languageEnglish
Pages (from-to)959-967
Number of pages9
JournalOpen Medicine (Poland)
Publication statusPublished - 2019


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