Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society

Winfried Randerath, Claudio L Bassetti, Maria R Bonsignore, Ramon Farre, Luigi Ferini-Strambi, Ludger Grote, Jan Hedner, Malcolm Kohler, Miguel Martinez-Garcia, Stefan Mihaicuta, Josep Montserrat, Jean-Louis Pepin, Dirk Pevernagie, Fabio Pizza, Olli Polo, Renata Riha, Silke Ryan, Johan Verbraecken, Walter T McNicholas

Research output: Contribution to journalReview article

Abstract

Obstructive sleep apnoea (OSA) is a major challenge for physicians and health care systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating co-morbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications, and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes, and relevant co-morbidities such as non-dipping nocturnal blood pressure. Furthermore, current severity thresholds require revision to reflect factors such as disparity in apnoea-hypopnoea frequency (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond the AHI.

Original languageEnglish
JournalEuropean Respiratory Journal
DOIs
Publication statusE-pub ahead of print - May 31 2018

Fingerprint Dive into the research topics of 'Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society'. Together they form a unique fingerprint.

  • Cite this

    Randerath, W., Bassetti, C. L., Bonsignore, M. R., Farre, R., Ferini-Strambi, L., Grote, L., Hedner, J., Kohler, M., Martinez-Garcia, M., Mihaicuta, S., Montserrat, J., Pepin, J-L., Pevernagie, D., Pizza, F., Polo, O., Riha, R., Ryan, S., Verbraecken, J., & McNicholas, W. T. (2018). Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society. European Respiratory Journal. https://doi.org/10.1183/13993003.02616-2017