Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society

W Randerath, CL Bassetti, Maria R Bonsignore, R Farre, L Ferini-Strambi, L Grote, J Hedner, M Kohler, M Martinez-Garcia, S Mihaicuta, J Montserrat, JL Pepin, D Pevernagie, F Pizza, O Polo, R Riha, S Ryan, J Verbraecken, WT McNicholas

Research output: Contribution to journalArticle

Abstract

Obstructive sleep apnoea (OSA) is a major challenge for physicians and health care systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating co-morbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications, and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes, and relevant co-morbidities such as non-dipping nocturnal blood pressure. Furthermore, current severity thresholds require revision to reflect factors such as disparity in apnoea-hypopnoea frequency (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond the AHI. Copyright ©ERS 2018.
Original languageEnglish
Article number1702616
JournalEuropean Respiratory Journal
Volume52
Issue number3
DOIs
Publication statusPublished - 2018

Fingerprint

Sleep Apnea Syndromes
Obstructive Sleep Apnea
Morbidity
Phenotype
Polysomnography
Sleep Stages
Apnea
Publications
Sleep
Epidemiology
Therapeutics
Blood Pressure
Delivery of Health Care
Physicians
Pressure

Cite this

Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society. / Randerath, W; Bassetti, CL; Bonsignore, Maria R; Farre, R; Ferini-Strambi, L; Grote, L; Hedner, J; Kohler, M; Martinez-Garcia, M; Mihaicuta, S; Montserrat, J; Pepin, JL; Pevernagie, D; Pizza, F; Polo, O; Riha, R; Ryan, S; Verbraecken, J; McNicholas, WT.

In: European Respiratory Journal, Vol. 52, No. 3, 1702616, 2018.

Research output: Contribution to journalArticle

Randerath, W, Bassetti, CL, Bonsignore, MR, Farre, R, Ferini-Strambi, L, Grote, L, Hedner, J, Kohler, M, Martinez-Garcia, M, Mihaicuta, S, Montserrat, J, Pepin, JL, Pevernagie, D, Pizza, F, Polo, O, Riha, R, Ryan, S, Verbraecken, J & McNicholas, WT 2018, 'Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society', European Respiratory Journal, vol. 52, no. 3, 1702616. https://doi.org/10.1183/13993003.02616-2017
Randerath, W ; Bassetti, CL ; Bonsignore, Maria R ; Farre, R ; Ferini-Strambi, L ; Grote, L ; Hedner, J ; Kohler, M ; Martinez-Garcia, M ; Mihaicuta, S ; Montserrat, J ; Pepin, JL ; Pevernagie, D ; Pizza, F ; Polo, O ; Riha, R ; Ryan, S ; Verbraecken, J ; McNicholas, WT. / Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society. In: European Respiratory Journal. 2018 ; Vol. 52, No. 3.
@article{009e7549532e468e8da10ec345716658,
title = "Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society",
abstract = "Obstructive sleep apnoea (OSA) is a major challenge for physicians and health care systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating co-morbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5{\^a}€…years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications, and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes, and relevant co-morbidities such as non-dipping nocturnal blood pressure. Furthermore, current severity thresholds require revision to reflect factors such as disparity in apnoea-hypopnoea frequency (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond the AHI. Copyright {\^A}{\circledC}ERS 2018.",
author = "W Randerath and CL Bassetti and Bonsignore, {Maria R} and R Farre and L Ferini-Strambi and L Grote and J Hedner and M Kohler and M Martinez-Garcia and S Mihaicuta and J Montserrat and JL Pepin and D Pevernagie and F Pizza and O Polo and R Riha and S Ryan and J Verbraecken and WT McNicholas",
year = "2018",
doi = "10.1183/13993003.02616-2017",
language = "English",
volume = "52",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "3",

}

TY - JOUR

T1 - Challenges and Perspectives in Obstructive Sleep Apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society

AU - Randerath, W

AU - Bassetti, CL

AU - Bonsignore, Maria R

AU - Farre, R

AU - Ferini-Strambi, L

AU - Grote, L

AU - Hedner, J

AU - Kohler, M

AU - Martinez-Garcia, M

AU - Mihaicuta, S

AU - Montserrat, J

AU - Pepin, JL

AU - Pevernagie, D

AU - Pizza, F

AU - Polo, O

AU - Riha, R

AU - Ryan, S

AU - Verbraecken, J

AU - McNicholas, WT

PY - 2018

Y1 - 2018

N2 - Obstructive sleep apnoea (OSA) is a major challenge for physicians and health care systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating co-morbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications, and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes, and relevant co-morbidities such as non-dipping nocturnal blood pressure. Furthermore, current severity thresholds require revision to reflect factors such as disparity in apnoea-hypopnoea frequency (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond the AHI. Copyright ©ERS 2018.

AB - Obstructive sleep apnoea (OSA) is a major challenge for physicians and health care systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating co-morbidities.An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications, and optimal treatment of patients with OSA.The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes, and relevant co-morbidities such as non-dipping nocturnal blood pressure. Furthermore, current severity thresholds require revision to reflect factors such as disparity in apnoea-hypopnoea frequency (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond the AHI. Copyright ©ERS 2018.

U2 - 10.1183/13993003.02616-2017

DO - 10.1183/13993003.02616-2017

M3 - Article

VL - 52

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 3

M1 - 1702616

ER -