Challenges and perspectives of quantitative functional sodium imaging (fNaI)

Claudia A.M. Gandini Wheeler-Kingshott, Frank Riemer, Fulvia Palesi, Antonio Ricciardi, Gloria Castellazzi, Xavier Golay, Ferran Prados, Bhavana Solanky, Egidio U. D’Angelo

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Brain function has been investigated via the blood oxygenation level dependent (BOLD) effect using magnetic resonance imaging (MRI) for the past decades. Advances in sodium imaging offer the unique chance to access signal changes directly linked to sodium ions (23Na) flux across the cell membrane, which generates action potentials, hence signal transmission in the brain. During this process 23Na transiently accumulates in the intracellular space. Here we show that quantitative functional sodium imaging (fNaI) at 3T is potentially sensitive to 23Na concentration changes during finger tapping, which can be quantified in gray and white matter regions key to motor function. For the first time, we measured a 23Na concentration change of 0.54 mmol/l in the ipsilateral cerebellum, 0.46 mmol/l in the contralateral primary motor cortex (M1), 0.27 mmol/l in the corpus callosum and -11 mmol/l in the ipsilateral M1, suggesting that fNaI is sensitive to distributed functional alterations. Open issues persist on the role of the glymphatic system in maintaining 23Na homeostasis, the role of excitation and inhibition as well as volume distributions during neuronal activity. Haemodynamic and physiological signal recordings coupled to realistic models of tissue function will be critical to understand the mechanisms of such changes and contribute to meeting the overarching challenge of measuring neuronal activity in vivo.

Original languageEnglish
Article number810
JournalFrontiers in Neuroscience
Volume12
Issue numberNOV
DOIs
Publication statusPublished - Nov 9 2018

Fingerprint

Sodium
Intracellular Space
Corpus Callosum
Motor Cortex
Brain
Cerebellum
Action Potentials
Fingers
Homeostasis
Hemodynamics
Magnetic Resonance Imaging
Cell Membrane
Ions

Keywords

  • BOLD
  • Functional imaging
  • MRI
  • Neuronal activity
  • Sodium imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gandini Wheeler-Kingshott, C. A. M., Riemer, F., Palesi, F., Ricciardi, A., Castellazzi, G., Golay, X., ... D’Angelo, E. U. (2018). Challenges and perspectives of quantitative functional sodium imaging (fNaI). Frontiers in Neuroscience, 12(NOV), [810]. https://doi.org/10.3389/fnins.2018.00810

Challenges and perspectives of quantitative functional sodium imaging (fNaI). / Gandini Wheeler-Kingshott, Claudia A.M.; Riemer, Frank; Palesi, Fulvia; Ricciardi, Antonio; Castellazzi, Gloria; Golay, Xavier; Prados, Ferran; Solanky, Bhavana; D’Angelo, Egidio U.

In: Frontiers in Neuroscience, Vol. 12, No. NOV, 810, 09.11.2018.

Research output: Contribution to journalReview article

Gandini Wheeler-Kingshott, CAM, Riemer, F, Palesi, F, Ricciardi, A, Castellazzi, G, Golay, X, Prados, F, Solanky, B & D’Angelo, EU 2018, 'Challenges and perspectives of quantitative functional sodium imaging (fNaI)', Frontiers in Neuroscience, vol. 12, no. NOV, 810. https://doi.org/10.3389/fnins.2018.00810
Gandini Wheeler-Kingshott CAM, Riemer F, Palesi F, Ricciardi A, Castellazzi G, Golay X et al. Challenges and perspectives of quantitative functional sodium imaging (fNaI). Frontiers in Neuroscience. 2018 Nov 9;12(NOV). 810. https://doi.org/10.3389/fnins.2018.00810
Gandini Wheeler-Kingshott, Claudia A.M. ; Riemer, Frank ; Palesi, Fulvia ; Ricciardi, Antonio ; Castellazzi, Gloria ; Golay, Xavier ; Prados, Ferran ; Solanky, Bhavana ; D’Angelo, Egidio U. / Challenges and perspectives of quantitative functional sodium imaging (fNaI). In: Frontiers in Neuroscience. 2018 ; Vol. 12, No. NOV.
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