Challenges and prospects of immunotherapy as cancer treatment

Maria Rescigno, Francesca Avogadri, Giuseppe Curigliano

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The concept of cancer immunotherapy stems from the proposed function of the immune system, called immunosurveillance, to protect against growing tumors. Due to genetic aberrations, tumor cells display an altered repertoire of MHC-associated peptides that can lead to the activation of immune cells able to eliminate the transformed cells. In some instances, under the pressure of the immune system, both the tumor and its microenvironment are shaped and immune-resistant tumor variants are selected initiating the process of cancer immunoediting. This can impair not only host-generated immunosurveillance, but also attempts to harness the immune response for therapeutic purposes, namely immunotherapy. Rather than being an exhaustive review of the different approaches of cancer immunotherapy, the focus of this review is to provide the reader with future challenges of the field by proposing 'second generation' immunotherapy approaches that take into account immunosubversive mechanisms adopted by tumor cells. After an introduction on the process of immunosurveillance and immunoescape we will analyze why current immunotherapy approaches have not fulfilled their promise and will finish by summarizing what are the challenges for future approaches.

Original languageEnglish
Pages (from-to)108-123
Number of pages16
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1776
Issue number1
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Immunotherapy
Immunologic Monitoring
Neoplasms
Therapeutics
Immune System
Tumor Microenvironment
Pressure
Peptides

Keywords

  • Cancer immunoediting
  • Clinical trial
  • Dendritic cell
  • Immunoevasion
  • Immunotherapy
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Biophysics
  • Cancer Research
  • Oncology

Cite this

Challenges and prospects of immunotherapy as cancer treatment. / Rescigno, Maria; Avogadri, Francesca; Curigliano, Giuseppe.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1776, No. 1, 08.2007, p. 108-123.

Research output: Contribution to journalArticle

@article{553876a71cdd4089aaaad4aca72ed588,
title = "Challenges and prospects of immunotherapy as cancer treatment",
abstract = "The concept of cancer immunotherapy stems from the proposed function of the immune system, called immunosurveillance, to protect against growing tumors. Due to genetic aberrations, tumor cells display an altered repertoire of MHC-associated peptides that can lead to the activation of immune cells able to eliminate the transformed cells. In some instances, under the pressure of the immune system, both the tumor and its microenvironment are shaped and immune-resistant tumor variants are selected initiating the process of cancer immunoediting. This can impair not only host-generated immunosurveillance, but also attempts to harness the immune response for therapeutic purposes, namely immunotherapy. Rather than being an exhaustive review of the different approaches of cancer immunotherapy, the focus of this review is to provide the reader with future challenges of the field by proposing 'second generation' immunotherapy approaches that take into account immunosubversive mechanisms adopted by tumor cells. After an introduction on the process of immunosurveillance and immunoescape we will analyze why current immunotherapy approaches have not fulfilled their promise and will finish by summarizing what are the challenges for future approaches.",
keywords = "Cancer immunoediting, Clinical trial, Dendritic cell, Immunoevasion, Immunotherapy, Monoclonal antibodies",
author = "Maria Rescigno and Francesca Avogadri and Giuseppe Curigliano",
year = "2007",
month = "8",
doi = "10.1016/j.bbcan.2007.07.003",
language = "English",
volume = "1776",
pages = "108--123",
journal = "Biochimica et Biophysica Acta - Reviews on Cancer",
issn = "0304-419X",
publisher = "Elsevier B.V.",
number = "1",

}

TY - JOUR

T1 - Challenges and prospects of immunotherapy as cancer treatment

AU - Rescigno, Maria

AU - Avogadri, Francesca

AU - Curigliano, Giuseppe

PY - 2007/8

Y1 - 2007/8

N2 - The concept of cancer immunotherapy stems from the proposed function of the immune system, called immunosurveillance, to protect against growing tumors. Due to genetic aberrations, tumor cells display an altered repertoire of MHC-associated peptides that can lead to the activation of immune cells able to eliminate the transformed cells. In some instances, under the pressure of the immune system, both the tumor and its microenvironment are shaped and immune-resistant tumor variants are selected initiating the process of cancer immunoediting. This can impair not only host-generated immunosurveillance, but also attempts to harness the immune response for therapeutic purposes, namely immunotherapy. Rather than being an exhaustive review of the different approaches of cancer immunotherapy, the focus of this review is to provide the reader with future challenges of the field by proposing 'second generation' immunotherapy approaches that take into account immunosubversive mechanisms adopted by tumor cells. After an introduction on the process of immunosurveillance and immunoescape we will analyze why current immunotherapy approaches have not fulfilled their promise and will finish by summarizing what are the challenges for future approaches.

AB - The concept of cancer immunotherapy stems from the proposed function of the immune system, called immunosurveillance, to protect against growing tumors. Due to genetic aberrations, tumor cells display an altered repertoire of MHC-associated peptides that can lead to the activation of immune cells able to eliminate the transformed cells. In some instances, under the pressure of the immune system, both the tumor and its microenvironment are shaped and immune-resistant tumor variants are selected initiating the process of cancer immunoediting. This can impair not only host-generated immunosurveillance, but also attempts to harness the immune response for therapeutic purposes, namely immunotherapy. Rather than being an exhaustive review of the different approaches of cancer immunotherapy, the focus of this review is to provide the reader with future challenges of the field by proposing 'second generation' immunotherapy approaches that take into account immunosubversive mechanisms adopted by tumor cells. After an introduction on the process of immunosurveillance and immunoescape we will analyze why current immunotherapy approaches have not fulfilled their promise and will finish by summarizing what are the challenges for future approaches.

KW - Cancer immunoediting

KW - Clinical trial

KW - Dendritic cell

KW - Immunoevasion

KW - Immunotherapy

KW - Monoclonal antibodies

UR - http://www.scopus.com/inward/record.url?scp=34548223215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548223215&partnerID=8YFLogxK

U2 - 10.1016/j.bbcan.2007.07.003

DO - 10.1016/j.bbcan.2007.07.003

M3 - Article

VL - 1776

SP - 108

EP - 123

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

SN - 0304-419X

IS - 1

ER -