Challenges of prevention for a sustainable personalized medicine

Roberta Pastorino, Claudia Loreti, Silvia Giovannini, Walter Ricciardi, Luca Padua, Stefania Boccia

Research output: Contribution to journalReview articlepeer-review


The development and implementation of the approaches of personalized medicine for disease prevention are still at infancy, although preventive activities in healthcare represent a key pillar to guarantee health system sustainability. There is an increasing interest in finding informative markers that indicate the disease risk before the manifestation of the disease (primary prevention) or for early disease detection (secondary prevention). Recently, the systematic collection and study of clinical phenotypes and biomarkers consented to the advance of Rehabilomics in tertiary prevention. It consents to identify relevant molecular and physiological factors that can be linked to plasticity, treatment response, and natural recovery. Implementation of these approaches would open avenues to identify people at high risk and enable new preventive lifestyle interventions or early treatments targeted to their individual genomic profile, personalizing prevention and rehabilitation. The integration of personalized medicine into prevention may benefit citizens, patients, healthcare professionals, healthcare authorities, and industry, and ultimately will seek to contribute to better health and quality of life for Europe’s citizens.

Original languageEnglish
Article number311
JournalJournal of Personalized Medicine
Issue number4
Publication statusPublished - 2021


  • Personalized medicine
  • Polygenic risk score
  • Prevention
  • Rehabilomics

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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