Challenges with optimizing nutrition in cystic fibrosis

Carla Colombo, Rita Maria Nobili, Gianfranco Alicandro

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction. Optimizing nutrition remains the cornerstone of therapy for patients with cystic fibrosis (CF) since it is associated with better pulmonary function and survival. However, a significant proportion of patients still fail to achieve normal growth and nutritional status. Areas covered. This review describes the current challenges in providing effective nutritional therapy in CF with a focus on the current issues related to energy imbalance, dietary composition, adherence to nutritional recommendations, pancreatic enzyme replacement therapy, and the effects of modulators of the CF transmembrane conductance regulator. Expert opinion. CF is a multisystemic disease that requires a personalized nutritional approach with accurate evaluation of energy balance. There is an urgent need for evidence-based recommendations on the dietary composition, in consideration of the increasing prevalence of overweight, diabetes and the potential effects of fatty acids on inflammation and immune response. More research into new pancreatic enzyme formulations is also required.

Original languageEnglish
Pages (from-to)533-544
Number of pages12
JournalExpert Review of Respiratory Medicine
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 3 2019

Keywords

  • adherence
  • Cystic fibrosis
  • diet
  • new therapies
  • nutrition

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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