Change in cardiac geometry and function in CKD children during strict BP control: A randomized study

Maria Chiara Matteucci, Marcello Chinali, Gabriele Rinelli, Elke Wühl, Aleksandra Zurowska, Marina Charbit, Giacomo Pongiglione, Franz Schaefer

Research output: Contribution to journalArticlepeer-review

Abstract

Background and objectives Left ventricular hypertrophy (LVH) and abnormal systolic function are present in a high proportion of children with CKD. This study evaluated changes in left ventricular (LV) geometry and systolic function in children with mild to moderate CKD as an ancillary project of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of Chronic Renal Failure in Pediatric Patients trial. Design, setting, participants, & measurements Echocardiograms and ambulatory BP monitoring were performed at baseline and at 1- or 2-year follow-up in 84 patients with CKD and 24-hour mean BP above the 50th percentile and/or receiving fixed high-dose angiotensin converting enzyme inhibition and randomized to conventional or intensified BP control. Results LVH prevalence decreased from 38% to 25% (P2.7; P

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 7 2013

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine

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