Change in major amputation rate in a center dedicated to diabetic foot care during the 1980s: Prognostic determinants for major amputation

Ezio Faglia, Fabrizio Favales, Antonio Aldeghi, Patrizia Calia, Antonella Quarantiello, Pierremigio Barbano, Maurizio Puttini, Bruno Palmieri, Giorgio Brambilla, Antonio Rampoldi, Ester Mazzola, Luigi Valenti, Gianfranco Fattori, Vincenzo Rega, Aldo Cristalli, Giorgio Oriani, Michael Michael, Alberto Morabito

Research output: Contribution to journalArticlepeer-review


From 1990 to 1993, 115 diabetic patients were consecutively hospitalized in our diabetologic unit for foot ulcer and 27 (23.5%) major amputations were carried out. The major amputation rate of this series of cases was compared with that occurring in diabetic subjects taken into our hospital for foot ulcer in two previous periods: 1979-1981 (17 major amputations in 42 inpatients or 40.5%) and 1986-1989 (26 major amputations in 78 inpatients or 33.3%). The comparison shows a progressive reduction in major amputation rate [Odds ratio 0.66, 95% confidence interval (CI) 0.46-0.96]. Univariate and multivariate analysis, carried out in the population of the 1990-1993 period, in order to detect the independent factors associated with major amputation show the following prognostic determinants of major amputation: Wagner grade (odds ratio 7.69, CI 1.58-37.53), prior stroke (odds ratio 35.05, CI 3.14-390.53), prior major amputation (odds ratio 3.49, CI 1.26-9.38), transcutaneous oxygen level (odds ratio 1.06, CI 1.01-1.12), and ankle-brachial blood pressure index (odds ratio 4.35, CI 1.58-12.05), while an independent protective role was attributed to hyperbaric oxygen treatment (odds ratio 0.15, CI 0.03-0.64). In accordance with other studies, we, therefore, conclude that a comprehensive protocol as well as a multidisciplinary approach in a dedicated center can assure a decrease in major amputation rate. The parameters of limb perfusion were the modifiable prognostic determinants most strongly predictive for amputation.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalJournal of Diabetes and its Complications
Issue number2
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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