Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD

Lara Pisani, Luca Fasano, Nadia Corcione, Vittoria Comellini, Muriel Assunta Musti, Maria Brandao, Damiano Bottone, Edoardo Calderini, Paolo Navalesi, Stefano Nava

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10â €..min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-Term management of patients with stable hypercapnic COPD. Trial registration number NCT02363920.

Original languageEnglish
Pages (from-to)373-375
Number of pages3
JournalThorax
Volume72
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • COPD Pathology
  • Long Term Oxygen Therapy (LTOT)
  • Non invasive ventilation
  • Respiratory Measurement

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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