We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10â €..min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-Term management of patients with stable hypercapnic COPD. Trial registration number NCT02363920.
- COPD Pathology
- Long Term Oxygen Therapy (LTOT)
- Non invasive ventilation
- Respiratory Measurement
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine