TY - JOUR
T1 - Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD
AU - Pisani, Lara
AU - Fasano, Luca
AU - Corcione, Nadia
AU - Comellini, Vittoria
AU - Musti, Muriel Assunta
AU - Brandao, Maria
AU - Bottone, Damiano
AU - Calderini, Edoardo
AU - Navalesi, Paolo
AU - Nava, Stefano
PY - 2017/4/1
Y1 - 2017/4/1
N2 - We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10â €..min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-Term management of patients with stable hypercapnic COPD. Trial registration number NCT02363920.
AB - We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10â €..min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-Term management of patients with stable hypercapnic COPD. Trial registration number NCT02363920.
KW - COPD Pathology
KW - Long Term Oxygen Therapy (LTOT)
KW - Non invasive ventilation
KW - Respiratory Measurement
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U2 - 10.1136/thoraxjnl-2016-209673
DO - 10.1136/thoraxjnl-2016-209673
M3 - Article
AN - SCOPUS:85011017784
VL - 72
SP - 373
EP - 375
JO - Thorax
JF - Thorax
SN - 0040-6376
IS - 4
ER -