Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli, AMD-Annals Study Grp

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Methods: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Results: Mean age at baseline was 65 +/- 9 years, known duration of diabetes11 +/- 8 years, eGFR 85 +/- 13 ml/min and BP 142 +/- 17/81 +/- 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR
Original languageEnglish
Pages (from-to)1719-1728
Number of pages10
JournalJournal of Hypertension
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Keywords

  • albuminuria
  • glomerular filtration rate
  • hypertension
  • type 2 diabetes

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