Abstract
Objectives: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Methods: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Results: Mean age at baseline was 65 +/- 9 years, known duration of diabetes11 +/- 8 years, eGFR 85 +/- 13 ml/min and BP 142 +/- 17/81 +/- 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR
Original language | English |
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Pages (from-to) | 1719-1728 |
Number of pages | 10 |
Journal | Journal of Hypertension |
Volume | 36 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1 2018 |
Keywords
- albuminuria
- glomerular filtration rate
- hypertension
- type 2 diabetes