Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

Francesca Viazzi; Antonio Ceriello; Paola Fioretto; Carlo Giorda; Pietro Guida; Giuseppina Russo; Eulalia Greco; Salvatore De Cosmo; Roberto Pontremoli; AMD-Annals Study Grp

doi:10.1097/HJH.0000000000001749

Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli, AMD-Annals Study Grp

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Methods: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Results: Mean age at baseline was 65 +/- 9 years, known duration of diabetes11 +/- 8 years, eGFR 85 +/- 13 ml/min and BP 142 +/- 17/81 +/- 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR

Original language	English
Pages (from-to)	1719-1728
Number of pages	10
Journal	Journal of Hypertension
Volume	36
Issue number	8
DOIs	https://doi.org/10.1097/HJH.0000000000001749
Publication status	Published - Aug 1 2018

Keywords

albuminuria
glomerular filtration rate
hypertension
type 2 diabetes

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10.1097/HJH.0000000000001749

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Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study. / Viazzi, Francesca; Ceriello, Antonio; Fioretto, Paola; Giorda, Carlo; Guida, Pietro; Russo, Giuseppina; Greco, Eulalia; De Cosmo, Salvatore; Pontremoli, Roberto; Grp, AMD-Annals Study.

In: Journal of Hypertension, Vol. 36, No. 8, 01.08.2018, p. 1719-1728.

Research output: Contribution to journal › Article › peer-review

Viazzi, Francesca ; Ceriello, Antonio ; Fioretto, Paola ; Giorda, Carlo ; Guida, Pietro ; Russo, Giuseppina ; Greco, Eulalia ; De Cosmo, Salvatore ; Pontremoli, Roberto ; Grp, AMD-Annals Study. / Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study. In: Journal of Hypertension. 2018 ; Vol. 36, No. 8. pp. 1719-1728.

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abstract = "Objectives: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Methods: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Results: Mean age at baseline was 65 +/- 9 years, known duration of diabetes11 +/- 8 years, eGFR 85 +/- 13 ml/min and BP 142 +/- 17/81 +/- 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR ",

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author = "Francesca Viazzi and Antonio Ceriello and Paola Fioretto and Carlo Giorda and Pietro Guida and Giuseppina Russo and Eulalia Greco and {De Cosmo}, Salvatore and Roberto Pontremoli and Grp, {AMD-Annals Study}",

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AU - Giorda, Carlo

AU - Guida, Pietro

AU - Russo, Giuseppina

AU - Greco, Eulalia

AU - De Cosmo, Salvatore

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