Abstract
Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 640-645 |
| Number of pages | 6 |
| Journal | British Journal of Haematology |
| Volume | 163 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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Keywords
- Angiogenesis
- Hypoxia-inducible factor-1α
- Indolent non-Hodgkin lymphomas
- Pathogenesis
- Relapse/progression
ASJC Scopus subject areas
- Hematology
Cite this
Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas. / Minoia, Carla; Quero, Carmela; Asselti, Mariaconsilia; Galise, Ida; Marzano, Alessia L.; Iacobazzi, Angela; Rana, Antonio; Merchionne, Francesca; Serratì, Simona; De Tullio, Giacoma; Quintana, Giovanni; Casiello, Michela; Maiorano, Eugenio; Simone, Giovanni; Zito, Francesco A.; Iacopino, Pasquale; Guarini, Attilio.
In: British Journal of Haematology, Vol. 163, No. 5, 12.2013, p. 640-645.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas
AU - Minoia, Carla
AU - Quero, Carmela
AU - Asselti, Mariaconsilia
AU - Galise, Ida
AU - Marzano, Alessia L.
AU - Iacobazzi, Angela
AU - Rana, Antonio
AU - Merchionne, Francesca
AU - Serratì, Simona
AU - De Tullio, Giacoma
AU - Quintana, Giovanni
AU - Casiello, Michela
AU - Maiorano, Eugenio
AU - Simone, Giovanni
AU - Zito, Francesco A.
AU - Iacopino, Pasquale
AU - Guarini, Attilio
PY - 2013/12
Y1 - 2013/12
N2 - Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
AB - Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
KW - Angiogenesis
KW - Hypoxia-inducible factor-1α
KW - Indolent non-Hodgkin lymphomas
KW - Pathogenesis
KW - Relapse/progression
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UR - http://www.scopus.com/inward/citedby.url?scp=84887615505&partnerID=8YFLogxK
U2 - 10.1111/bjh.12560
DO - 10.1111/bjh.12560
M3 - Article
VL - 163
SP - 640
EP - 645
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 5
ER -