Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas

Carla Minoia; Carmela Quero; Mariaconsilia Asselti; Ida Galise; Alessia L. Marzano; Angela Iacobazzi; Antonio Rana; Francesca Merchionne; Simona Serratì; Giacoma De Tullio; Giovanni Quintana; Michela Casiello; Eugenio Maiorano; Giovanni Simone; Francesco A. Zito; Pasquale Iacopino; Attilio Guarini

doi:10.1111/bjh.12560

Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas

Carla Minoia, Carmela Quero, Mariaconsilia Asselti, Ida Galise, Alessia L. Marzano, Angela Iacobazzi, Antonio Rana, Francesca Merchionne, Simona Serratì, Giacoma De Tullio, Giovanni Quintana, Michela Casiello, Eugenio Maiorano, Giovanni Simone, Francesco A. Zito, Pasquale Iacopino, Attilio Guarini

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

Original language	English
Pages (from-to)	640-645
Number of pages	6
Journal	British Journal of Haematology
Volume	163
Issue number	5
DOIs	https://doi.org/10.1111/bjh.12560
Publication status	Published - Dec 2013

Keywords

Angiogenesis
Hypoxia-inducible factor-1α
Indolent non-Hodgkin lymphomas
Pathogenesis
Relapse/progression

ASJC Scopus subject areas

Hematology

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10.1111/bjh.12560

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Minoia, C., Quero, C., Asselti, M., Galise, I., Marzano, A. L., Iacobazzi, A., Rana, A., Merchionne, F., Serratì, S., De Tullio, G., Quintana, G., Casiello, M., Maiorano, E., Simone, G., Zito, F. A., Iacopino, P., & Guarini, A. (2013). Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas. British Journal of Haematology, 163(5), 640-645. https://doi.org/10.1111/bjh.12560

Minoia, C, Quero, C, Asselti, M, Galise, I, Marzano, AL, Iacobazzi, A, Rana, A, Merchionne, F, Serratì, S, De Tullio, G, Quintana, G, Casiello, M, Maiorano, E, Simone, G, Zito, FA, Iacopino, P & Guarini, A 2013, 'Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas', British Journal of Haematology, vol. 163, no. 5, pp. 640-645. https://doi.org/10.1111/bjh.12560

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abstract = "Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.",

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author = "Carla Minoia and Carmela Quero and Mariaconsilia Asselti and Ida Galise and Marzano, {Alessia L.} and Angela Iacobazzi and Antonio Rana and Francesca Merchionne and Simona Serrat{\`i} and {De Tullio}, Giacoma and Giovanni Quintana and Michela Casiello and Eugenio Maiorano and Giovanni Simone and Zito, {Francesco A.} and Pasquale Iacopino and Attilio Guarini",

year = "2013",

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doi = "10.1111/bjh.12560",

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AU - Minoia, Carla

AU - Quero, Carmela

AU - Asselti, Mariaconsilia

AU - Galise, Ida

AU - Marzano, Alessia L.

AU - Iacobazzi, Angela

AU - Rana, Antonio

AU - Merchionne, Francesca

AU - Serratì, Simona

AU - De Tullio, Giacoma

AU - Quintana, Giovanni

AU - Casiello, Michela

AU - Maiorano, Eugenio

AU - Simone, Giovanni

AU - Zito, Francesco A.

AU - Iacopino, Pasquale

AU - Guarini, Attilio

PY - 2013/12

Y1 - 2013/12

N2 - Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

AB - Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

KW - Angiogenesis

KW - Hypoxia-inducible factor-1α

KW - Indolent non-Hodgkin lymphomas

KW - Pathogenesis

KW - Relapse/progression

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Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas

Abstract

Keywords

ASJC Scopus subject areas

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