Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas

Carla Minoia, Carmela Quero, Mariaconsilia Asselti, Ida Galise, Alessia L. Marzano, Angela Iacobazzi, Antonio Rana, Francesca Merchionne, Simona Serratì, Giacoma De Tullio, Giovanni Quintana, Michela Casiello, Eugenio Maiorano, Giovanni Simone, Francesco A. Zito, Pasquale Iacopino, Attilio Guarini

Research output: Contribution to journalArticle

Abstract

Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

Original languageEnglish
Pages (from-to)640-645
Number of pages6
JournalBritish Journal of Haematology
Volume163
Issue number5
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Angiogenesis
  • Hypoxia-inducible factor-1α
  • Indolent non-Hodgkin lymphomas
  • Pathogenesis
  • Relapse/progression

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Minoia, C., Quero, C., Asselti, M., Galise, I., Marzano, A. L., Iacobazzi, A., Rana, A., Merchionne, F., Serratì, S., De Tullio, G., Quintana, G., Casiello, M., Maiorano, E., Simone, G., Zito, F. A., Iacopino, P., & Guarini, A. (2013). Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas. British Journal of Haematology, 163(5), 640-645. https://doi.org/10.1111/bjh.12560