Abstract
Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.
Original language | English |
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Pages (from-to) | 640-645 |
Number of pages | 6 |
Journal | British Journal of Haematology |
Volume | 163 |
Issue number | 5 |
DOIs | |
Publication status | Published - Dec 2013 |
Keywords
- Angiogenesis
- Hypoxia-inducible factor-1α
- Indolent non-Hodgkin lymphomas
- Pathogenesis
- Relapse/progression
ASJC Scopus subject areas
- Hematology