TY - JOUR
T1 - Changes in body composition during neoadjuvant therapy can affect prognosis in rectal cancer patients
T2 - An exploratory study
AU - De Nardi, Paola
AU - Salandini, Mariachiara
AU - Chiari, Damiano
AU - Pecorelli, Nicolò
AU - Cristel, Giulia
AU - Damascelli, Anna
AU - Ronzoni, Monica
AU - Massimino, Luca
AU - De Cobelli, Francesco
AU - Braga, Marco
N1 - Publisher Copyright:
© 2019
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Aim: To establish the correlation between changes in body composition after neoadjuvant chemoradiotherapy (nCRT) and postoperative outcomes, in patients with advanced low rectal cancer. Methods: Patients with clinical stage T≥3 or N+ rectal cancer who underwent nCRT and surgical resection were studied. Skeletal muscle, visceral, and subcutaneous fat cross-sectional area were measured by computed tomography before and after nCRT. Postoperative morbidity, pathologic response to nCRT, overall and disease-free survival was assessed. Results: Fifty-two patients, median age 62 (range 32-79) were studied. A skeletal muscle loss >2% significantly correlated with a shorter disease-free survival both in the overall population (P = 0.048) and in the subgroup of N0 patients (P = 0.048). A subcutaneous fat loss >5% was also associated with a shorter disease-free survival (P = 0.012) in the whole population. Conclusions: Skeletal muscle loss, after neoadjuvant chemoradiotherapy, negatively impacts on disease-free survival in surgically treated rectal cancer patients.
AB - Aim: To establish the correlation between changes in body composition after neoadjuvant chemoradiotherapy (nCRT) and postoperative outcomes, in patients with advanced low rectal cancer. Methods: Patients with clinical stage T≥3 or N+ rectal cancer who underwent nCRT and surgical resection were studied. Skeletal muscle, visceral, and subcutaneous fat cross-sectional area were measured by computed tomography before and after nCRT. Postoperative morbidity, pathologic response to nCRT, overall and disease-free survival was assessed. Results: Fifty-two patients, median age 62 (range 32-79) were studied. A skeletal muscle loss >2% significantly correlated with a shorter disease-free survival both in the overall population (P = 0.048) and in the subgroup of N0 patients (P = 0.048). A subcutaneous fat loss >5% was also associated with a shorter disease-free survival (P = 0.012) in the whole population. Conclusions: Skeletal muscle loss, after neoadjuvant chemoradiotherapy, negatively impacts on disease-free survival in surgically treated rectal cancer patients.
KW - Body composition changes
KW - Neoadjuvant chemoradiotherapy
KW - Rectal cancer
KW - Skeletal muscle loss
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U2 - 10.1016/j.currproblcancer.2019.100510
DO - 10.1016/j.currproblcancer.2019.100510
M3 - Review article
C2 - 31703987
AN - SCOPUS:85075444740
VL - 44
JO - Current Problems in Cancer
JF - Current Problems in Cancer
SN - 0147-0272
IS - 2
M1 - 100510
ER -