Changes in cerebello-motor connectivity during procedural learning by actual execution and observation

Sara Torriero, Massimiliano Oliveri, Giacomo Koch, Emanuele Lo Gerfo, Silvia Salerno, Fabio Ferlazzo, Carlo Caltagirone, Laura Petrosini

Research output: Contribution to journalArticlepeer-review

Abstract

The cerebellum is involved in motor learning of new procedures both during actual execution of a motor task and during observational training. These processes are thought to depend on the activity of a neural network that involves the lateral cerebellum and primary motor cortex (M1). In this study, we used a twin-coil TMS technique to investigate whether execution and observation of a visuomotor procedural learning task is related to modulation of cerebello-motor connectivity. We observed that, at rest, a magnetic conditioning pulse applied over the lateral cerebellum reduced the motor-evoked potentials obtained by stimulating the contralateral M1, indicating activation of a cerebello-motor connection. Furthermore, during procedural learning, cerebellar stimulation resulted in selective facilitation, not inhibition, of contralateral M1 excitability. The effects were evident when motor learning was obtained by actual execution of the task or by observation, but they disappeared if procedural learning had already been acquired by previous observational training. These results indicate that changes in cerebello-motor connectivity occur in relation to specific phases of procedural learning, demonstrating a complex pattern of excitatory and inhibitory drives modulated across time.

Original languageEnglish
Pages (from-to)338-348
Number of pages11
JournalJournal of Cognitive Neuroscience
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2011

ASJC Scopus subject areas

  • Cognitive Neuroscience

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