Changes in cerebral hemodynamics during laparoscopic cholecystectomy

Germano De Cosmo, Enrico Iannace, Paolo Primieri, Maria R. Valente, Rodolfo Proietti, Maria Matteis, Mauro Silvestrini

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Laparoscopic surgery requires a series of procedures, including intraperitoneal CO2 insufflation, which can cause cardiovascular and hemogasanalytic modifications, potentially able to impair cerebral perfusion. The aim of this study was to evaluate changes in cerebral blood flow velocity during laparoscopic cholecystectomy. Eighteen patients undergoing laparoscopic cholecystectomy were studied. Middle cerebral artery blood flow velocity was monitored using transcranial Doppler ultrasonography. Electrical bioimpedance was employed to measure cardiac output, stroke volume and to calculate derived parameters. End-tidal CO2, mean arterial blood pressure, end expiratory anesthetic concentration and O2 saturation were monitored non-invasively. Cerebral artery blood flow velocity increased significantly after CO2 insufflation (p <0.05) and remained stable. The highest values were reached after CO2 desufflation. A significant reduction in stroke volume and cardiac output (p <0.05) associated with increased vascular systemic resistances (p <0.001) was observed soon after CO2 insufflation. The decrease in cardiac output and the increase in vascular systemic resistances remained significant throughout abdominal insufflation. Heart rate and mean arterial pressure remained substantially unchanged with the exception of a significant decrease (p <0.001) before CO2 insufflation. There was no significant change in end-tidal CO2 during abdominal insufflation. These findings suggest that the cerebrovascular system can undergo adaptive changes during all phases of laparoscopic surgery. However, the extent of cardio- and cerebrovascular variation indicates the need for careful preliminary evaluation of cerebral hemodynamics in patients with vascular disorders before laparoscopic surgery.

Original languageEnglish
Pages (from-to)658-660
Number of pages3
JournalNeurological Research
Volume21
Issue number7
Publication statusPublished - Oct 1999

Fingerprint

Insufflation
Laparoscopic Cholecystectomy
Cerebrovascular Circulation
Hemodynamics
Blood Flow Velocity
Cardiac Output
Laparoscopy
Arterial Pressure
Vascular Resistance
Stroke Volume
Doppler Transcranial Ultrasonography
Cerebral Arteries
Middle Cerebral Artery
Blood Vessels
Anesthetics
Perfusion
Heart Rate

Keywords

  • Cerebral hemodynamics
  • Laparoscopic surgery
  • Transcranial Doppler ultrasonography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

De Cosmo, G., Iannace, E., Primieri, P., Valente, M. R., Proietti, R., Matteis, M., & Silvestrini, M. (1999). Changes in cerebral hemodynamics during laparoscopic cholecystectomy. Neurological Research, 21(7), 658-660.

Changes in cerebral hemodynamics during laparoscopic cholecystectomy. / De Cosmo, Germano; Iannace, Enrico; Primieri, Paolo; Valente, Maria R.; Proietti, Rodolfo; Matteis, Maria; Silvestrini, Mauro.

In: Neurological Research, Vol. 21, No. 7, 10.1999, p. 658-660.

Research output: Contribution to journalArticle

De Cosmo, G, Iannace, E, Primieri, P, Valente, MR, Proietti, R, Matteis, M & Silvestrini, M 1999, 'Changes in cerebral hemodynamics during laparoscopic cholecystectomy', Neurological Research, vol. 21, no. 7, pp. 658-660.
De Cosmo G, Iannace E, Primieri P, Valente MR, Proietti R, Matteis M et al. Changes in cerebral hemodynamics during laparoscopic cholecystectomy. Neurological Research. 1999 Oct;21(7):658-660.
De Cosmo, Germano ; Iannace, Enrico ; Primieri, Paolo ; Valente, Maria R. ; Proietti, Rodolfo ; Matteis, Maria ; Silvestrini, Mauro. / Changes in cerebral hemodynamics during laparoscopic cholecystectomy. In: Neurological Research. 1999 ; Vol. 21, No. 7. pp. 658-660.
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