Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy

Enrico Borrelli, Giacinto Triolo, Maria L. Cascavilla, Chiara La Morgia, Giovanni Rizzo, Giacomo Savini, Nicole Balducci, Paolo Nucci, Rosa Giglio, Fatemeh Darvizeh, Vincenzo Parisi, Francesco Bandello, Alfredo Arrigo Sadun, Valerio Carelli, Piero Barboni

Research output: Contribution to journalArticle

Abstract

Leber's hereditary optic neuropathy (LHON) is typically characterized by vascular alterations in the acute phase. The aim of this study was to evaluate choroidal changes occurring in asymptomatic, acute and chronic stages of LHON. We enrolled 49 patients with LHON, 19 with Dominant Optic Atrophy (DOA) and 22 healthy controls. Spectral Domain-Optical Coherence Tomography (SD-OCT) scans of macular and peripapillary regions were performed in all subjects, to evaluate macular and peripapillary choroidal thickness, and retinal nerve fiber layer (RNFL) thicknes. Macular and peripapillary choroidal thicknesses were significantly increased in the acute LHON stage. On the contrary, macular choroidal thickness was significantly reduced in the chronic stage. Furthermore, peripapillary choroidal thickness was decreased in chronic LHON and in DOA. Both RNFL and choroid had the same trend (increased thickness, followed by thinning), but RNFL changes preceded those affecting the choroid. In conclusion, our study quantitatively demonstrated the involvement of the choroid in LHON pathology. The increase in choroidal thickness is a feature of the LHON acute stage, which follows the thickening of RNFL. Conversely, thinning of the choroid is the common outcome in chronic LHON and in DOA.

Original languageEnglish
Article number37332
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Nov 17 2016

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Leber's Hereditary Optic Atrophy
Nerve Fibers
Autosomal Dominant Optic Atrophy
Choroid
Optical Coherence Tomography
Blood Vessels
Pathology

ASJC Scopus subject areas

  • General

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Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy. / Borrelli, Enrico; Triolo, Giacinto; Cascavilla, Maria L.; La Morgia, Chiara; Rizzo, Giovanni; Savini, Giacomo; Balducci, Nicole; Nucci, Paolo; Giglio, Rosa; Darvizeh, Fatemeh; Parisi, Vincenzo; Bandello, Francesco; Sadun, Alfredo Arrigo; Carelli, Valerio; Barboni, Piero.

In: Scientific Reports, Vol. 6, 37332, 17.11.2016.

Research output: Contribution to journalArticle

Borrelli, E, Triolo, G, Cascavilla, ML, La Morgia, C, Rizzo, G, Savini, G, Balducci, N, Nucci, P, Giglio, R, Darvizeh, F, Parisi, V, Bandello, F, Sadun, AA, Carelli, V & Barboni, P 2016, 'Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy', Scientific Reports, vol. 6, 37332. https://doi.org/10.1038/srep37332
Borrelli, Enrico ; Triolo, Giacinto ; Cascavilla, Maria L. ; La Morgia, Chiara ; Rizzo, Giovanni ; Savini, Giacomo ; Balducci, Nicole ; Nucci, Paolo ; Giglio, Rosa ; Darvizeh, Fatemeh ; Parisi, Vincenzo ; Bandello, Francesco ; Sadun, Alfredo Arrigo ; Carelli, Valerio ; Barboni, Piero. / Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy. In: Scientific Reports. 2016 ; Vol. 6.
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