Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon

Lorena Duca; Alessandro Da Ponte; Mariarita Cozzi; Annalisa Carbone; Mauro Pomati; Isabella Nava; Maria Domenica Cappellini; Gemino Fiorelli

doi:10.1007/BF02934717

Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon

Lorena Duca, Alessandro Da Ponte, Mariarita Cozzi, Annalisa Carbone, Mauro Pomati, Isabella Nava, Maria Domenica Cappellini, Gemino Fiorelli

Research output: Contribution to journal › Article › peer-review

Abstract

In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron status and oxidative indices before, immediately and 48 h after a race in 8 healthy trained males aged 33-44 years running a 21-km marathon in 79±3 min. The haematological parameters were determined by standard procedures. Erythropoietin and soluble-transferrin receptor were evaluated immunoenzymatically. Nontransferrin-bound iron (NTBI) was assayed by high-performance liquid chromatography after nitrilotriacetic acid chelation. Malonyldialdehyde (MDA) concentration was assayed colorimetrically. The total number of reticulocytes rose significantly after the run with a significant increase in the high-RNA-content fraction (14±5, p

Original language	English
Pages (from-to)	30-34
Number of pages	5
Journal	Internal and Emergency Medicine
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/BF02934717
Publication status	Published - Apr 2006

Keywords

Exercise
Malonyldialdehyde
Reticulocytes
Transferrin receptors

ASJC Scopus subject areas

Emergency Medicine
Internal Medicine

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10.1007/BF02934717

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title = "Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon",

abstract = "In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron status and oxidative indices before, immediately and 48 h after a race in 8 healthy trained males aged 33-44 years running a 21-km marathon in 79±3 min. The haematological parameters were determined by standard procedures. Erythropoietin and soluble-transferrin receptor were evaluated immunoenzymatically. Nontransferrin-bound iron (NTBI) was assayed by high-performance liquid chromatography after nitrilotriacetic acid chelation. Malonyldialdehyde (MDA) concentration was assayed colorimetrically. The total number of reticulocytes rose significantly after the run with a significant increase in the high-RNA-content fraction (14±5, p",

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author = "Lorena Duca and {Da Ponte}, Alessandro and Mariarita Cozzi and Annalisa Carbone and Mauro Pomati and Isabella Nava and Cappellini, {Maria Domenica} and Gemino Fiorelli",

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AU - Da Ponte, Alessandro

AU - Cozzi, Mariarita

AU - Carbone, Annalisa

AU - Pomati, Mauro

AU - Nava, Isabella

AU - Cappellini, Maria Domenica

AU - Fiorelli, Gemino

PY - 2006/4

Y1 - 2006/4

N2 - In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron status and oxidative indices before, immediately and 48 h after a race in 8 healthy trained males aged 33-44 years running a 21-km marathon in 79±3 min. The haematological parameters were determined by standard procedures. Erythropoietin and soluble-transferrin receptor were evaluated immunoenzymatically. Nontransferrin-bound iron (NTBI) was assayed by high-performance liquid chromatography after nitrilotriacetic acid chelation. Malonyldialdehyde (MDA) concentration was assayed colorimetrically. The total number of reticulocytes rose significantly after the run with a significant increase in the high-RNA-content fraction (14±5, p

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KW - Exercise

KW - Malonyldialdehyde

KW - Reticulocytes

KW - Transferrin receptors

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Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon

Abstract

Keywords

ASJC Scopus subject areas

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