Changes in erythropoiesis, iron metabolism and oxidative stress after half-marathon

Lorena Duca, Alessandro Da Ponte, Mariarita Cozzi, Annalisa Carbone, Mauro Pomati, Isabella Nava, Maria Domenica Cappellini, Gemino Fiorelli

Research output: Contribution to journalArticlepeer-review


In marathon runners changes in red blood cell count, haematocrit and haemoglobin in relation to haemodilution have been reported. Moreover, it has been hypothesized that strenous exercise induces oxidant stress through several different mechanisms. This study investigated the haematological variables, iron status and oxidative indices before, immediately and 48 h after a race in 8 healthy trained males aged 33-44 years running a 21-km marathon in 79±3 min. The haematological parameters were determined by standard procedures. Erythropoietin and soluble-transferrin receptor were evaluated immunoenzymatically. Nontransferrin-bound iron (NTBI) was assayed by high-performance liquid chromatography after nitrilotriacetic acid chelation. Malonyldialdehyde (MDA) concentration was assayed colorimetrically. The total number of reticulocytes rose significantly after the run with a significant increase in the high-RNA-content fraction (14±5, p

Original languageEnglish
Pages (from-to)30-34
Number of pages5
JournalInternal and Emergency Medicine
Issue number1
Publication statusPublished - Apr 2006


  • Exercise
  • Malonyldialdehyde
  • Reticulocytes
  • Transferrin receptors

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine


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