Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment

G. F. Gensini, D. Prisco, P. G. Rogasi, M. Matucci, G. G. Neri Serneri

Research output: Contribution to journalArticle

Abstract

In a single-blind cross-over study the effect of oral treatment with pantethine on plasma and platelet lipid composition was evaluated in 20 patients with dyslipidaemia (7 IIa, 7 IIb and 6 IV type). In plasma significant decreases of total cholesterol and triglycerides with increase of high density lipoprotein-cholesterol were observed. In platelets pantethine treatment significantly reduced phospholipid and cholesterol content. In addition gas-chromatographic analysis showed a reduction of saturated and monounsaturated and a relative increase of polyunsaturated fatty acid content of platelet phospholipids. A selective relative increase was observed of some n-3 polyunsaturated fatty acids like eicosapentaenoic and docosahexaenoic acid whereas arachidonic acid decreased. The present study indicates a favourable influence of pantethine not only on plasma but also on platelet lipids which could be of value in delaying the development of atherosclerosis in dyslipidaemic patients.

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalInternational Journal of Clinical Pharmacology Research
Volume5
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Gensini, G. F., Prisco, D., Rogasi, P. G., Matucci, M., & Neri Serneri, G. G. (1985). Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment. International Journal of Clinical Pharmacology Research, 5(5), 309-318.