Changes in human plasma nerve growth factor level after chronic alcohol consumption and withdrawal

L. Aloe, M. A. Tuveri, G. Guerra, L. Pinna, P. Tirassa, A. Micera, E. Alleva

Research output: Contribution to journalArticlepeer-review

Abstract

Numerous studies reported in recent years have shown that withdrawal from chronic consumption of drugs induces high levels of anxiety, both in humans and in animal models. In the present study, we demonstrated that withdrawal from chronic consumption of either ethanol or heroin causes a significant increase in plasma nerve growth factor, suggesting that the resulting anxiety condition triggers the release of this molecule. Although the functional significance of this phenomenon needs to be better defined, it is hypothesized that the increased levels of circulating nerve growth factor might be involved in homeostatic adaptive and/or reparative mechanisms.

Original languageEnglish
Pages (from-to)462-465
Number of pages4
JournalAlcoholism: Clinical and Experimental Research
Volume20
Issue number3
Publication statusPublished - 1996

Keywords

  • Alcoholism
  • Anxiety
  • Heroin
  • Nerve Growth Factor
  • Withdrawal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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