Changes in insulin levels following 6-month treatment with recombinant human growth hormone in growth hormone-deficient adults

D. Valle, M. N D Di Minno, V. Palmieri, S. Pezzullo, F. Cirillo, C. Di Somma, G. Di Minno, G. Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Eighty-six adult patients with GH deficiency (GHD) of adult or childhood onset were treated for 6 months, with recombinant human growth hormone (r-hGH) at a low (LD) or conventional dose (CD). The treatment effect on insulin levels was investigated. Methods: This manuscript refers to the Italian addendum to an International Study (B9R-EW-GDED) in which patients with GHD were randomized to receive r-hGH replacement therapy at a dose of either 3 μg/kg/day or 6 μg/kg/day for the 3 months. The dose was then doubled for the next 3 months. Results: After 6 months of r-hGH treatment, insulin levels increased with both GH dosages, with a greater increase achieved in the low-dose subgroup. Insulin levels also increased significantly in the childhood-onset, while even decreased in the adult-onset subgroup. On the whole, in more than 50% of patients, insulin values rose by >13%. Moreover, mean levels of IGF-I increased 2-3 fold (p

Original languageEnglish
Pages (from-to)908-912
Number of pages5
JournalJournal of Endocrinological Investigation
Volume32
Issue number11
DOIs
Publication statusPublished - Dec 2009

Keywords

  • GH-deficient adults
  • IGF-I
  • Insulin
  • r-hGH treatment
  • Recombinant human growth hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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