Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals

Mario Clerici, Frances T. Hakim, David J. Venzon, Stephen Blatt, Craig W. Hendrix, Thomas A. Wynn, Gene M. Shearer

Research output: Contribution to journalArticlepeer-review

Abstract

Infection with HIV results in an incremental loss of T helper cell (TH) function, which can occur years before CD4 cell numbers are critically reduced and AIDS is diagnosed. All TH function is not affected, however, because B cell activation and hypergammaglobulinema are also characteristic of this period. Recently, in a murine model of AIDS an early loss in production of the CD4 cytokines IL-2 and IFN-γ was correlated with an increase in the B cell stimulatory cytokines IL-4, IL-5, and IL-10. We therefore assessed the production of IL-4 generated by PBL from HIV-seropositive (HIV+) individuals who did not have AIDS, yet who exhibited different TH functional categories based on their IL-2 production profiles. We observed that the decreases in recall antigen-stimulated IL-2 production were accompanied by an increase in IL-4 production. The loss of recall antigen-stimulated responses in HIV+ individuals could be reversed in vitro by anti-IL-4 antibody. Our results suggest that the TH functions assessed by IL-4 production replace the normally dominant TH function of antigen-stimulated IL-2 production in the progression toward AIDS, and raise the possibility of cytokine cross-regulation in AIDS therapy.

Original languageEnglish
Pages (from-to)759-765
Number of pages7
JournalJournal of Clinical Investigation
Volume91
Issue number3
Publication statusPublished - Mar 1993

Keywords

  • Human immunodeficiency virus infection
  • Interleukin-10
  • Interleukin-2
  • Interleukin-4
  • T lymphocytes

ASJC Scopus subject areas

  • Medicine(all)

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