Changes in intestinal permeability to lactulose induced by cytotoxic chemotherapy

G. Parrilli, R. V. Iaffaioli, G. Capuano, G. Budillon, A. R. Bianco

Research output: Contribution to journalArticlepeer-review

Abstract

Intestinal function during cytotoxic therapy was studied in nine patients with nonintestinal lymphoma. An early, marked, and rapidly reversible increase in passive permeability, as disclosed by the lactulose test, was observed without concomitant changes in active absorption or in intestinal histology. The possibility of a toxic effect by cytotoxic drugs on intestinal intracellular junctions is discussed.

Original languageEnglish
Pages (from-to)1435-1436
Number of pages2
JournalCancer Treatment Reports
Volume66
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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