Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum

Giacomo Koch, Francesco Mori, Barbara Marconi, Claudia Codecà, Cristiano Pecchioli, Silvia Salerno, Sara Torriero, Emanuele Lo Gerfo, Pablo Mir, Massimiliano Oliveri, Carlo Caltagirone

Research output: Contribution to journalArticle

Abstract

Objective: The cerebellum takes part in several motor functions through its influence on the motor cortex (M1). Here, we applied the theta burst stimulation (TBS) protocol, a novel form of repetitive Transcranial Magnetic Stimulation (rTMS) over the lateral cerebellum. The aim of this study was to test whether TBS of the lateral cerebellum could be able to modulate the excitability of the contralateral M1 in healthy subjects. Methods: Motor-evoked potentials (MEPs) amplitude, short intracortical inhibition (SICI), long intracortical inhibition (LICI) and short intracortical facilitation (SICF) were tested in the M1 before and after cerebellar continuous TBS (cTBS) or intermittent TBS (iTBS). Results: We found that cTBS induced a reduction of SICI and an increase of LICI. On the other hand, cerebellar iTBS reduced LICI. MEPs amplitude also differently vary following cerebellar stimulation with cTBS or iTBS, resulting in a decrease by the former and an increase by the latter. Conclusions: Although the interpretation of these data remains highly speculative, these findings reveal that the cerebellar cortex undergoes bidirectional plastic changes that modulate different intracortical circuits within the contralateral primary motor cortex. Significance: Long-lasting modifications of these pathways could be useful to treat various pathological conditions characterized by an altered cortical excitability.

Original languageEnglish
Pages (from-to)2559-2569
Number of pages11
JournalClinical Neurophysiology
Volume119
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • Cerebellum
  • Connectivity
  • Intracortical inhibition
  • Theta burst stimulation
  • TMS
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Fingerprint Dive into the research topics of 'Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum'. Together they form a unique fingerprint.

  • Cite this

    Koch, G., Mori, F., Marconi, B., Codecà, C., Pecchioli, C., Salerno, S., Torriero, S., Lo Gerfo, E., Mir, P., Oliveri, M., & Caltagirone, C. (2008). Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum. Clinical Neurophysiology, 119(11), 2559-2569. https://doi.org/10.1016/j.clinph.2008.08.008