Changes in muscle esterases in genetically dystrophic and control littermate mice

R. Bianchi, M. Paro, G. Ghidotti, E. Mussini

Research output: Contribution to journalArticle

Abstract

The hypothesis that the existence of a family of isoenzymes is at the basis of the heterogeneity of esterase activity among skeletal muscles from dystrophic Re 129J and control littermate mice were tested using isoelectrofocusing (IEF) in polacrylamide gel. All muscles considered showed not only quantitative heterogeneity, as previously observed in this laboratory, but also qualitative differences with regard to their esterase isoenzymes. Differences in the number and the relative amounts of isoenzymatic bands were found between different muscles from both control and dystrophic animals. In most dystrophic muscles a new isoenzymatic band appeared at pH 6.6. Another band, identified at pH 5.12, was more pronounced in dystrophic than in control muscles. The specificity of these observations is indirectly supported by the fact that other tissue, such as heart, liver, and kidney, did not show the quantitative or qualitative abnormality present in the dystrophic skeletal muscles.

Original languageEnglish
Pages (from-to)485-489
Number of pages5
JournalMuscle and Nerve
Volume5
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Bianchi, R., Paro, M., Ghidotti, G., & Mussini, E. (1982). Changes in muscle esterases in genetically dystrophic and control littermate mice. Muscle and Nerve, 5(6), 485-489.