Changes in Muscle Synergy Organization After Neurological Lesions

Denise J. Berger, F. Ferrari, A. Esposito, M. Masciullo, M. Molinari, F. Lacquaniti, Andrea D’Avella

Research output: Chapter in Book/Report/Conference proceedingChapter


The role of the cerebral cortex and the cerebellum in determining the spatiotemporal characteristics of the muscle activation patterns is still largely unknown. Recent studies suggest that the coordination of the muscles relies on flexible combinations of a few muscle synergies. We aim at gaining new insights on the neural organization of the muscle patterns for reaching by using multidimensional decomposition algorithms to identify muscle synergies in patients with damage to the cerebral cortex and to the cerebellum. Understanding the changes in the modular organization of the motor system after neurological lesions is highly relevant for upper limb rehabilitation because it may lead to the development of novel objective and quantitative indicators of motor impairment directly related to a specific pathophysiology.

Original languageEnglish
Title of host publicationBiosystems and Biorobotics
PublisherSpringer International Publishing AG
Number of pages5
Publication statusPublished - Jan 1 2017

Publication series

NameBiosystems and Biorobotics
ISSN (Print)2195-3562
ISSN (Electronic)2195-3570

ASJC Scopus subject areas

  • Artificial Intelligence
  • Biomedical Engineering
  • Mechanical Engineering


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