Despite a large clinical use, very little is known about sleep changes caused by carbamazepine (CBZ) administration in epileptic patients. Night sleep organisation and daytime somnolence have been studied in 7 temporal lobe epileptic patients and in 6 healthy controls in basal condition and after 400 mg of CBZ. Only patients have also been recorded after one month daily treatment with CBZ-CR 800 mg. In basal condition the epileptic patients do not differ from the control group. After the first CBZ administration, both groups present a reduction and fragmentation of REM sleep, and an increased daytime somnolence. After chronic use, sleep alteration tend to return to baseline. Finally, CBZ does not cause alterations of sleep microstructure.
|Translated title of the contribution||Changes in nocturnal sleep and day time somnolence after CBZ administration|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Clinical Neurology